U2AF2

UniProt Accession P26368 UniProt 🔗
Synonyms U2AF65
UniProt protein names Splicing factor U2AF 65 kDa subunit;
U2 auxiliary factor 65 kDa subunit;
U2 snRNP auxiliary factor large subunit
Peak binding time (min) 37.3
Cluster II
Cluster membership (corr) 0.999
Peak broadness (1 / std of log2 intensities) 0.85
Cluster expected from GO III
Subcellular localization (Human Protein Atlas) Nuclear speckles;Nucleoplasm
Subcellular localization (Human Cell Map) NMF result: nuclear body, SAFE result: -
RMSE (expected - observed) 0.20
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of U2AF2 in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
Q07955 SRSF1 41.6 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 4 4
P52272 HNRNPM 46.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 4 3
Q99590 SCAF11 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 4 3
P84103 SRSF3 43.0 II Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 4 3
Q9UHX1 PUF60 35.4 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 3 7
Q15637 SF1 40.9 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 3 6
O75533 SF3B1 40.9 II Nuclear speckles NMF result: no prediction, SAFE result: no prediction 3 4
Q99459 CDC5L 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 3 4
P23246 SFPQ 45.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 3 3
Q15393 SF3B3 45.7 II Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 3 3
P61978 HNRNPK 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 3 3
O43395 PRPF3 48.3 III Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 3 3
P31943 HNRNPH1 40.8 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 3 3
Q15233 NONO 42.9 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 3 3
O60506 SYNCRIP 71.4 V Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles 3 2
Q07666 KHDRBS1 43.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 3 2
Q15287 RNPS1 58.0 IV Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 2 4
P09012 SNRPA 44.9 III Nucleoplasm NMF result: no prediction, SAFE result: no prediction 2 4
Q13435 SF3B2 37.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 2 3
P08621 SNRNP70 32.2 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 2 3
Q14498 RBM39 30.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 2 2
P62314 SNRPD1 54.6 IV NMF result: nuclear body, SAFE result: spliceosomal complex I 2 2
Q15717 ELAVL1 46.3 III Cytosol;Nucleoli;Nucleus NMF result: miscellaneous, SAFE result: paraspeckles 2 2
Q96AE4 FUBP1 36.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
Q8IWZ8 SUGP1 32.9 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 2 2
Q13151 HNRNPA0 43.7 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
Q8WXF1 PSPC1 44.9 II Nucleoli fibrillar center;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
O43390 HNRNPR 48.0 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
Q16629 SRSF7 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 2 2
Q9Y383 LUC7L2 29.7 II Nucleus NMF result: ER lumen, SAFE result: - 2 2
Q16630 CPSF6 33.9 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 2 2
Q01130 SRSF2 41.6 II Cytosol;Nucleus NMF result: chromatin, SAFE result: - 2 2
P17844 DDX5 40.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
O75643 SNRNP200 42.7 II Nucleoplasm NMF result: nuclear body, SAFE result: spliceosomal complex I 2 2
Q9Y3B4 SF3B6 36.0 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 2 2
O14776 TCERG1 40.9 II Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 2 2
Q14103 HNRNPD 43.1 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
P07910 HNRNPC 47.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
Q92841 DDX17 39.2 II Nuclear speckles NMF result: nuclear body, SAFE result: paraspeckles 2 2
P62995 TRA2B 42.0 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 2 2
Q13838 DDX39B 67.1 V Nuclear speckles NMF result: nuclear body, SAFE result: no prediction 2 2
Q00839 HNRNPU 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
P14866 HNRNPL 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
Q13242 SRSF9 44.3 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
O00422 SAP18 63.4 IV Cytosol;Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 2 2
P12956 XRCC6 47.9 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 2
P52597 HNRNPF 42.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
O75494 SRSF10 46.3 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 2 2
Q8IX12 CCAR1 35.1 II Golgi apparatus;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
Q05519 SRSF11 52.0 III Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 2 1
Q12905 ILF2 48.0 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 2 1
P98175 RBM10 33.0 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 2 1
Q8IWX8 CHERP 23.2 II NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 2 1
Q15029 EFTUD2 45.5 III Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 2
Q9UKV3 ACIN1 60.5 IV Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 2
P19338 NCL 27.1 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q9H307 PNN 64.6 IV Nuclear speckles NMF result: nuclear body, SAFE result: spliceosomal complex II 1 2
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 2
Q86V81 ALYREF 71.2 V NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 2
P07900 HSP90AA1 48.1 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 2
Q15365 PCBP1 48.6 III Cytoplasmic bodies;Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 2
Q86VM9 ZC3H18 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 2
Q96SB4 SRPK1 52.0 IV Cytosol;Nucleus;Plasma membrane NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 2
Q13573 SNW1 51.8 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 2
Q9Y2W1 THRAP3 37.2 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 2
Q15428 SF3A2 31.3 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 2
Q13595 TRA2A 42.2 II Nucleoli;Vesicles NMF result: no prediction, SAFE result: no prediction 1 2
O75400 PRPF40A 39.8 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 2
Q08170 SRSF4 44.0 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q5T200 ZC3H13 38.4 II Actin filaments;Nuclear membrane NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P43243 MATR3 47.9 III NMF result: nuclear body, SAFE result: paraspeckles 1 1
O14979 HNRNPDL 43.3 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q92945 KHSRP 37.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P18583 SON 43.3 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P07814 EPRS 29.5 II Cytosol NMF result: actin cytoskeleton, cytosol, SAFE result: cell junction, plasma membrane 1 1
Q7RTV0 PHF5A 37.6 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q12906 ILF3 48.8 III Mitochondria;Nucleoli;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O43251 RBFOX2 45.8 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q6PKG0 LARP1 253.4 VII Cytosol;Endoplasmic reticulum;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q92804 TAF15 35.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q15427 SF3B4 38.3 II Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
Q9GZT3 SLIRP 71.4 V Mitochondria NMF result: no prediction, SAFE result: no prediction 1 1
Q08211 DHX9 50.2 III Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
P60842 EIF4A1 96.8 VI Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
O15143 ARPC1B 49.8 III Cytosol;Vesicles NMF result: no prediction, SAFE result: no prediction 1 1
Q9UKJ3 GPATCH8 61.2 IV Mitochondria;Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P63241 EIF5A 53.2 III Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q6Y7W6 GIGYF2 61.8 IV Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P38159 RBMX 44.4 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P82979 SARNP 70.0 V Nuclear speckles NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q15459 SF3A1 43.6 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q00610 CLTC 33.4 II Cytosol;Mitotic spindle;Vesicles NMF result: actin cytoskeleton, cytosol, SAFE result: no prediction 1 1
P22626 HNRNPA2B1 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q12873 CHD3 52.4 IV Microtubule organizing center;Nucleoli;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q13148 TARDBP 49.3 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q86U42 PABPN1 44.3 II NMF result: no prediction, SAFE result: no prediction 1 1
Q9UBU9 NXF1 50.3 III Nucleoplasm NMF result: miscellaneous, SAFE result: nuclear pore 1 1
P63244 RACK1 43.3 III Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P49761 CLK3 52.9 III Intermediate filaments;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P62826 RAN 44.7 III NMF result: no prediction, SAFE result: no prediction 1 1
Q9H7B2 RPF2 69.1 V Nucleoli;Nucleus NMF result: miscellaneous, SAFE result: - 1 1
P46013 MKI67 62.1 V Nuclear bodies;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
O15234 CASC3 88.1 VI Nuclear membrane NMF result: no prediction, SAFE result: no prediction 1 1
Q9NR30 DDX21 0.0 I Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
P09429 HMGB1 49.8 III Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q12986 NFX1 77.5 V Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q92900 UPF1 158.9 VII Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
O00571 DDX3X 146.2 VII Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q9BWF3 RBM4 40.3 II Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P11142 HSPA8 45.1 III Nucleoplasm;Vesicles NMF result: miscellaneous, SAFE result: no prediction 1 1
Q9H7N4 SCAF1 31.3 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9Y3Y2 CHTOP 75.6 V Nuclear speckles NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q8IYB3 SRRM1 39.4 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9NQ29 LUC7L 43.6 II Mitochondria;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q01844 EWSR1 36.3 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
P11021 HSPA5 48.9 III Cytosol NMF result: ER lumen, SAFE result: ER lumen 1 1
P07437 TUBB 34.3 II Microtubules NMF result: no prediction, SAFE result: no prediction 1 1
O43290 SART1 39.6 II Golgi apparatus;Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q92879 CELF1 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q5TC82 RC3H1 62.0 IV Cytosol;Plasma membrane NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q9UQ35 SRRM2 42.5 III Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q8NC51 SERBP1 213.4 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P24928 POLR2A 0.0 I Nucleoplasm NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm 1 1
P06748 NPM1 56.1 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P08238 HSP90AB1 46.0 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
O95793 STAU1 111.0 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q13243 SRSF5 41.7 II Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
O95218 ZRANB2 54.2 III Nucleus NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P11387 TOP1 48.2 III Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
P26599 PTBP1 46.5 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13310 PABPC4 147.7 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P51991 HNRNPA3 43.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P14618 PKM 44.0 III Cytosol NMF result: miscellaneous, SAFE result: no prediction 1 1
P09651 HNRNPA1 43.1 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q9NYF8 BCLAF1 37.5 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q14980 NUMA1 47.8 III Nucleoplasm NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q15424 SAFB 45.0 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P52756 RBM5 33.5 II Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P11940 PABPC1 124.3 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q15056 EIF4H 115.6 VI Cytosol;Nuclear bodies;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: - 1 1
Q14839 CHD4 61.8 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q96PU8 QKI 47.1 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P29401 TKT 46.5 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q9HCD5 NCOA5 43.1 II Actin filaments;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q6NZY4 ZCCHC8 40.2 II Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: - 1 1
O94906 PRPF6 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: spliceosomal complex I 1 1
P67809 YBX1 148.5 VII Cytosol;Vesicles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q13247 SRSF6 45.9 II Nuclear speckles NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
Q14152 EIF3A 198.2 VII Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q7KZF4 SND1 245.8 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q9UQ80 PA2G4 53.8 IV Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
P68104 EEF1A1 42.8 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
P38919 EIF4A3 67.1 V Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
O15042 U2SURP 33.1 II Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P26038 MSN 40.3 II Plasma membrane NMF result: actin cytoskeleton, cytosol, SAFE result: cell junction, plasma membrane 1 1
Q13123 IK 51.9 IV Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9BXS6 NUSAP1 52.2 III Nucleoli fibrillar center;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q9UKM9 RALY 48.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O43143 DHX15 35.8 II Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
Q9BY77 POLDIP3 74.6 V Cytoplasmic bodies;Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q99729 HNRNPAB 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P12270 TPR 53.6 IV Nuclear membrane NMF result: no prediction, SAFE result: no prediction 1 1