HSPA8
| UniProt Accession | P11142 UniProt 🔗 |
|---|---|
| Synonyms | HSC70, HSP73, HSPA10 |
| UniProt protein names | Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 8;Lipopolysaccharide-associated protein 1 |
| Peak binding time (min) | 45.1 |
| Cluster | III |
| Cluster membership (corr) | 0.991 |
| Peak broadness (1 / std of log2 intensities) | 1.52 |
| Cluster expected from GO | II |
| Subcellular localization (Human Protein Atlas) | Nucleoplasm;Vesicles |
| Subcellular localization (Human Cell Map) | NMF result: miscellaneous, SAFE result: no prediction |
| RMSE (expected - observed) | 0.26 |
| Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of HSPA8 in mRNP (BioGRID)
| Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
|---|---|---|---|---|---|---|---|
| P07900 | HSP90AA1 | 48.1 | III | Cytosol | NMF result: no prediction, SAFE result: no prediction | 4 | 8 |
| P08238 | HSP90AB1 | 46.0 | III | Cytosol | NMF result: no prediction, SAFE result: no prediction | 3 | 3 |
| P11021 | HSPA5 | 48.9 | III | Cytosol | NMF result: ER lumen, SAFE result: ER lumen | 2 | 5 |
| P07437 | TUBB | 34.3 | II | Microtubules | NMF result: no prediction, SAFE result: no prediction | 2 | 3 |
| Q14103 | HNRNPD | 43.1 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 3 |
| P68104 | EEF1A1 | 42.8 | III | Cytosol | NMF result: no prediction, SAFE result: no prediction | 2 | 3 |
| Q00610 | CLTC | 33.4 | II | Cytosol;Mitotic spindle;Vesicles | NMF result: actin cytoskeleton, cytosol, SAFE result: no prediction | 2 | 2 |
| Q99459 | CDC5L | 49.2 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 2 |
| P09429 | HMGB1 | 49.8 | III | Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 2 | 2 |
| P11940 | PABPC1 | 124.3 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 2 | 2 |
| P30876 | POLR2B | 0.0 | I | Nucleoplasm | NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm | 2 | 1 |
| Q69YN4 | VIRMA | 0.0 | I | Nuclear bodies;Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 1 |
| Q15428 | SF3A2 | 31.3 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 3 |
| O95793 | STAU1 | 111.0 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 3 |
| Q00341 | HDLBP | 171.5 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 2 |
| Q96CW1 | AP2M1 | 45.0 | III | Plasma membrane | NMF result: endosome, lysosome, SAFE result: endosome, lysosome | 1 | 2 |
| P35637 | FUS | 37.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 2 |
| O75534 | CSDE1 | 122.4 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 2 |
| Q13573 | SNW1 | 51.8 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 2 |
| Q4G0J3 | LARP7 | 54.3 | IV | Cytosol;Nucleoplasm | NMF result: nucleolus, SAFE result: paraspeckles | 1 | 2 |
| Q15459 | SF3A1 | 43.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 2 |
| Q13148 | TARDBP | 49.3 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 2 |
| Q15637 | SF1 | 40.9 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P43243 | MATR3 | 47.9 | III | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 | |
| P18583 | SON | 43.3 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P04406 | GAPDH | 42.0 | III | Cytosol;Plasma membrane | NMF result: mitochondrial outer membrane, peroxisome, SAFE result: - | 1 | 1 |
| P07814 | EPRS | 29.5 | II | Cytosol | NMF result: actin cytoskeleton, cytosol, SAFE result: cell junction, plasma membrane | 1 | 1 |
| Q15287 | RNPS1 | 58.0 | IV | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P21127 | CDK11B | 48.8 | III | Nuclear speckles | NMF result: chromatin, SAFE result: - | 1 | 1 |
| Q6PKG0 | LARP1 | 253.4 | VII | Cytosol;Endoplasmic reticulum;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q8TAD8 | SNIP1 | 40.9 | II | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q92804 | TAF15 | 35.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q08211 | DHX9 | 50.2 | III | Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P60842 | EIF4A1 | 96.8 | VI | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q96FZ2 | HMCES | 59.9 | IV | Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| E9PAV3 | NACA | 46.0 | III | Cytosol | NMF result: nucleolus, SAFE result: no prediction | 1 | 1 |
| Q8N684 | CPSF7 | 36.9 | II | Cytosol;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P78344 | EIF4G2 | 200.0 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q12873 | CHD3 | 52.4 | IV | Microtubule organizing center;Nucleoli;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| O14617 | AP3D1 | 43.2 | III | Cytosol | NMF result: endosome, lysosome, SAFE result: endosome, lysosome | 1 | 1 |
| P63244 | RACK1 | 43.3 | III | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P27694 | RPA1 | 45.5 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P62826 | RAN | 44.7 | III | NMF result: no prediction, SAFE result: no prediction | 1 | 1 | |
| Q00325 | SLC25A3 | 44.7 | II | Mitochondria | NMF result: plasma membrane, SAFE result: - | 1 | 1 |
| Q92499 | DDX1 | 74.7 | V | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9Y520 | PRRC2C | 147.3 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P12236 | SLC25A6 | 45.8 | III | Mitochondria | NMF result: mitochondrial matrix, SAFE result: no prediction | 1 | 1 |
| P61326 | MAGOH | 70.2 | V | Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P06733 | ENO1 | 36.6 | III | Cytosol;Plasma membrane | NMF result: miscellaneous, SAFE result: - | 1 | 1 |
| Q04637 | EIF4G1 | 105.0 | VI | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q12986 | NFX1 | 77.5 | V | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P17987 | TCP1 | 45.1 | III | NMF result: miscellaneous, SAFE result: chaperonin-containing T-complex, prefoldin complex | 1 | 1 | |
| Q92900 | UPF1 | 158.9 | VII | Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q92841 | DDX17 | 39.2 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q14527 | HLTF | 49.9 | III | Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q6P158 | DHX57 | 78.3 | VI | Cytosol;Intermediate filaments;Microtubules;Nucleoli | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q01844 | EWSR1 | 36.3 | II | Nucleoli;Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P57723 | PCBP4 | 47.4 | III | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9ULX6 | AKAP8L | 39.8 | II | Nuclear speckles | NMF result: miscellaneous, SAFE result: - | 1 | 1 |
| O14776 | TCERG1 | 40.9 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q5TC82 | RC3H1 | 62.0 | IV | Cytosol;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q9UQ35 | SRRM2 | 42.5 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q99700 | ATXN2 | 116.5 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| O43896 | KIF1C | 79.7 | V | NMF result: microtubule cytoskeleton, SAFE result: - | 1 | 1 | |
| Q9BXP5 | SRRT | 44.7 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: no prediction | 1 | 1 |
| Q07955 | SRSF1 | 41.6 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q7Z739 | YTHDF3 | 111.3 | VI | Cytosol;Nuclear membrane;Nuclear speckles | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q13310 | PABPC4 | 147.7 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9H6T0 | ESRP2 | 55.2 | IV | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P51991 | HNRNPA3 | 43.2 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P09651 | HNRNPA1 | 43.1 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P23588 | EIF4B | 213.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q15029 | EFTUD2 | 45.5 | III | Cytosol;Nucleoplasm | NMF result: miscellaneous, SAFE result: spliceosomal complex I | 1 | 1 |
| Q86VM9 | ZC3H18 | 39.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P48634 | PRRC2A | 106.7 | VI | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q14839 | CHD4 | 61.8 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q13838 | DDX39B | 67.1 | V | Nuclear speckles | NMF result: nuclear body, SAFE result: no prediction | 1 | 1 |
| Q9NZ01 | TECR | 43.4 | III | Endoplasmic reticulum | NMF result: mitochondrial outer membrane, peroxisome, SAFE result: - | 1 | 1 |
| Q9BQ52 | ELAC2 | 60.6 | III | Nucleoplasm | NMF result: mitochondrial matrix, SAFE result: mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix | 1 | 1 |
| P33992 | MCM5 | 42.8 | III | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P52272 | HNRNPM | 46.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P38919 | EIF4A3 | 67.1 | V | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P26368 | U2AF2 | 37.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: - | 1 | 1 |
| Q7L2J0 | MEPCE | 53.8 | III | Cell Junctions;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q12996 | CSTF3 | 9.6 | I | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q12874 | SF3A3 | 37.2 | II | Nucleoplasm | NMF result: chromatin, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| O43143 | DHX15 | 35.8 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q5VT52 | RPRD2 | 8.3 | I | Nucleoplasm;Vesicles | NMF result: nuclear body, SAFE result: spliceosomal complex II | 1 | 1 |