SRRM2
| UniProt Accession | Q9UQ35 UniProt 🔗 |
|---|---|
| Synonyms | HSPC075, KIAA0324, SRL300, SRM300 |
| UniProt protein names | Serine/arginine repetitive matrix protein 2;300 kDa nuclear matrix antigen;Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa;Splicing coactivator subunit SRm300;Tax-responsive enhancer element-binding protein 803 |
| Peak binding time (min) | 42.5 |
| Cluster | III |
| Cluster membership (corr) | 0.994 |
| Peak broadness (1 / std of log2 intensities) | 1.18 |
| Cluster expected from GO | III |
| Subcellular localization (Human Protein Atlas) | Nuclear speckles |
| Subcellular localization (Human Cell Map) | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus |
| RMSE (expected - observed) | 0.12 |
| Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of SRRM2 in mRNP (BioGRID)
| Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
|---|---|---|---|---|---|---|---|
| Q9H307 | PNN | 64.6 | IV | Nuclear speckles | NMF result: nuclear body, SAFE result: spliceosomal complex II | 3 | 3 |
| Q8IYB3 | SRRM1 | 39.4 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 4 |
| Q8TAD8 | SNIP1 | 40.9 | II | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 2 | 4 |
| P38919 | EIF4A3 | 67.1 | V | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 2 | 3 |
| Q86VM9 | ZC3H18 | 39.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 3 |
| P38159 | RBMX | 44.4 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
| Q15287 | RNPS1 | 58.0 | IV | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 2 |
| P68104 | EEF1A1 | 42.8 | III | Cytosol | NMF result: no prediction, SAFE result: no prediction | 2 | 2 |
| P09651 | HNRNPA1 | 43.1 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 2 | 2 |
| Q9Y5S9 | RBM8A | 77.3 | V | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 2 | 2 |
| Q99459 | CDC5L | 49.2 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 2 |
| Q15427 | SF3B4 | 38.3 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 2 | 2 |
| O75400 | PRPF40A | 39.8 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 2 | 2 |
| O94906 | PRPF6 | 39.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: spliceosomal complex I | 2 | 2 |
| P17844 | DDX5 | 40.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
| Q15393 | SF3B3 | 45.7 | II | Nucleoli;Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 2 | 2 |
| P31943 | HNRNPH1 | 40.8 | II | Cytosol;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
| P52272 | HNRNPM | 46.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
| Q15029 | EFTUD2 | 45.5 | III | Cytosol;Nucleoplasm | NMF result: miscellaneous, SAFE result: spliceosomal complex I | 1 | 2 |
| Q13243 | SRSF5 | 41.7 | II | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| P08621 | SNRNP70 | 32.2 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| Q96SB4 | SRPK1 | 52.0 | IV | Cytosol;Nucleus;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 2 |
| P49756 | RBM25 | 34.8 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 2 |
| Q14498 | RBM39 | 30.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: no prediction | 1 | 2 |
| Q13595 | TRA2A | 42.2 | II | Nucleoli;Vesicles | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| Q9NQ29 | LUC7L | 43.6 | II | Mitochondria;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| P49761 | CLK3 | 52.9 | III | Intermediate filaments;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| Q08170 | SRSF4 | 44.0 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P18583 | SON | 43.3 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q8N5F7 | NKAP | 47.0 | III | Cytosol;Nucleoplasm | NMF result: nuclear body, SAFE result: spliceosomal complex II | 1 | 1 |
| Q9H9J4 | USP42 | 45.6 | III | Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P62314 | SNRPD1 | 54.6 | IV | NMF result: nuclear body, SAFE result: spliceosomal complex I | 1 | 1 | |
| Q12906 | ILF3 | 48.8 | III | Mitochondria;Nucleoli;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q13573 | SNW1 | 51.8 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q15428 | SF3A2 | 31.3 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q6UN15 | FIP1L1 | 19.3 | I | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q08211 | DHX9 | 50.2 | III | Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P60842 | EIF4A1 | 96.8 | VI | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P82979 | SARNP | 70.0 | V | Nuclear speckles | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q15459 | SF3A1 | 43.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P22626 | HNRNPA2B1 | 42.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9Y383 | LUC7L2 | 29.7 | II | Nucleus | NMF result: ER lumen, SAFE result: - | 1 | 1 |
| Q15149 | PLEC | 59.3 | V | Cytosol;Focal adhesion sites;Intermediate filaments | NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched | 1 | 1 |
| Q92541 | RTF1 | 40.9 | II | Cytosol;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q92499 | DDX1 | 74.7 | V | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P61978 | HNRNPK | 42.6 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q15717 | ELAVL1 | 46.3 | III | Cytosol;Nucleoli;Nucleus | NMF result: miscellaneous, SAFE result: paraspeckles | 1 | 1 |
| P61326 | MAGOH | 70.2 | V | Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9NR30 | DDX21 | 0.0 | I | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P09429 | HMGB1 | 49.8 | III | Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q12986 | NFX1 | 77.5 | V | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| O00571 | DDX3X | 146.2 | VII | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| O15372 | EIF3H | 64.3 | IV | Cytosol | NMF result: centrosome, SAFE result: - | 1 | 1 |
| P11142 | HSPA8 | 45.1 | III | Nucleoplasm;Vesicles | NMF result: miscellaneous, SAFE result: no prediction | 1 | 1 |
| Q9UKV3 | ACIN1 | 60.5 | IV | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| O75643 | SNRNP200 | 42.7 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: spliceosomal complex I | 1 | 1 |
| Q00839 | HNRNPU | 42.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q13435 | SF3B2 | 37.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| O43395 | PRPF3 | 48.3 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P11021 | HSPA5 | 48.9 | III | Cytosol | NMF result: ER lumen, SAFE result: ER lumen | 1 | 1 |
| Q13523 | PRPF4B | 45.4 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P23246 | SFPQ | 45.2 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P78347 | GTF2I | 49.8 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| O43290 | SART1 | 39.6 | II | Golgi apparatus;Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q5TC82 | RC3H1 | 62.0 | IV | Cytosol;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q07955 | SRSF1 | 41.6 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P31942 | HNRNPH3 | 39.3 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q69YN4 | VIRMA | 0.0 | I | Nuclear bodies;Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P07910 | HNRNPC | 47.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9NP64 | ZCCHC17 | 44.4 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9UHX1 | PUF60 | 35.4 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P51991 | HNRNPA3 | 43.2 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q86V81 | ALYREF | 71.2 | V | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 | |
| P14866 | HNRNPL | 42.6 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| O75533 | SF3B1 | 40.9 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P11940 | PABPC1 | 124.3 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q14839 | CHD4 | 61.8 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q13838 | DDX39B | 67.1 | V | Nuclear speckles | NMF result: nuclear body, SAFE result: no prediction | 1 | 1 |
| Q05519 | SRSF11 | 52.0 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P67809 | YBX1 | 148.5 | VII | Cytosol;Vesicles | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q9BZZ5 | API5 | 69.0 | V | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q15233 | NONO | 42.9 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9Y580 | RBM7 | 36.4 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P12956 | XRCC6 | 47.9 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9BQ39 | DDX50 | 23.3 | II | Nucleoli | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P26368 | U2AF2 | 37.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: - | 1 | 1 |
| Q12905 | ILF2 | 48.0 | III | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P53999 | SUB1 | 43.3 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q02040 | AKAP17A | 60.8 | III | Cytosol;Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P37108 | SRP14 | 45.6 | III | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P52597 | HNRNPF | 42.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9UIG0 | BAZ1B | 44.3 | II | Nuclear bodies | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| O43143 | DHX15 | 35.8 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9BRP8 | PYM1 | 247.2 | VII | Cell Junctions;Cytosol;Nucleoli;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: - | 1 | 1 |
| O60506 | SYNCRIP | 71.4 | V | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles | 1 | 1 |
| Q9C0B0 | UNK | 88.4 | VI | Cytoplasmic bodies;Cytosol | NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched | 1 | 1 |
| O60231 | DHX16 | 48.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |