EIF3A
| UniProt Accession | Q14152 UniProt 🔗 |
|---|---|
| Synonyms | EIF3S10, KIAA0139 |
| UniProt protein names | Eukaryotic translation initiation factor 3 subunit A;Eukaryotic translation initiation factor 3 subunit 10;eIF-3-theta;eIF3 p167;eIF3 p180;eIF3 p185 |
| Peak binding time (min) | 198.2 |
| Cluster | VII |
| Cluster membership (corr) | 0.996 |
| Peak broadness (1 / std of log2 intensities) | 1.55 |
| Cluster expected from GO | VII |
| Subcellular localization (Human Protein Atlas) | Cytosol;Nucleus |
| Subcellular localization (Human Cell Map) | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule |
| RMSE (expected - observed) | 0.08 |
| Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of EIF3A in mRNP (BioGRID)
| Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
|---|---|---|---|---|---|---|---|
| O75821 | EIF3G | 105.9 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 5 | 8 |
| O15372 | EIF3H | 64.3 | IV | Cytosol | NMF result: centrosome, SAFE result: - | 4 | 9 |
| O15371 | EIF3D | 208.1 | VII | Cytosol | NMF result: miscellaneous, SAFE result: - | 4 | 8 |
| Q9Y262 | EIF3L | 193.3 | VII | Nucleoli;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 3 | 6 |
| P23588 | EIF4B | 213.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 3 | 2 |
| P60842 | EIF4A1 | 96.8 | VI | Cytosol | NMF result: no prediction, SAFE result: no prediction | 2 | 3 |
| O00571 | DDX3X | 146.2 | VII | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 2 | 2 |
| Q92900 | UPF1 | 158.9 | VII | Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 2 | 1 |
| Q69YN4 | VIRMA | 0.0 | I | Nuclear bodies;Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 1 |
| O95793 | STAU1 | 111.0 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 2 |
| B5ME19 | EIF3CL | 170.8 | VII | Cytosol | NMF result: miscellaneous, SAFE result: - | 1 | 2 |
| P19338 | NCL | 27.1 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| O43809 | NUDT21 | 41.6 | II | Nuclear bodies | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9Y5A9 | YTHDF2 | 111.0 | VI | Cytoplasmic bodies;Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q13283 | G3BP1 | 220.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P06748 | NPM1 | 56.1 | IV | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P26368 | U2AF2 | 37.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: - | 1 | 1 |
| Q7L2J0 | MEPCE | 53.8 | III | Cell Junctions;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q6PKG0 | LARP1 | 253.4 | VII | Cytosol;Endoplasmic reticulum;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P52597 | HNRNPF | 42.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q04637 | EIF4G1 | 105.0 | VI | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q4G0J3 | LARP7 | 54.3 | IV | Cytosol;Nucleoplasm | NMF result: nucleolus, SAFE result: paraspeckles | 1 | 1 |
| Q15029 | EFTUD2 | 45.5 | III | Cytosol;Nucleoplasm | NMF result: miscellaneous, SAFE result: spliceosomal complex I | 1 | 1 |
| Q86VM9 | ZC3H18 | 39.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q13148 | TARDBP | 49.3 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q15056 | EIF4H | 115.6 | VI | Cytosol;Nuclear bodies;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: - | 1 | 1 |
| Q00839 | HNRNPU | 42.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9C0B0 | UNK | 88.4 | VI | Cytoplasmic bodies;Cytosol | NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched | 1 | 1 |
| Q14839 | CHD4 | 61.8 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P78344 | EIF4G2 | 200.0 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q12873 | CHD3 | 52.4 | IV | Microtubule organizing center;Nucleoli;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |