NPM1

UniProt Accession P06748 UniProt 🔗
Synonyms NPM
UniProt protein names Nucleophosmin;
Nucleolar phosphoprotein B23;
Nucleolar protein NO38;
Numatrin
Peak binding time (min) 56.1
Cluster IV
Cluster membership (corr) 0.989
Peak broadness (1 / std of log2 intensities) 1.16
Cluster expected from GO IV
Subcellular localization (Human Protein Atlas) Nucleoli;Nucleus
Subcellular localization (Human Cell Map) NMF result: nucleolus, SAFE result: splicing speckles, nucleolus
RMSE (expected - observed) 0.02
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of NPM1 in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
P19338 NCL 27.1 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 4 6
Q9BVP2 GNL3 68.1 V Nuclear bodies;Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 4 2
Q9UQ80 PA2G4 53.8 IV Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 3 4
Q9P275 USP36 42.4 II Nuclear speckles;Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 3 3
Q9NR30 DDX21 0.0 I Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 2 4
Q00839 HNRNPU 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 3
P27695 APEX1 53.4 III Nucleus NMF result: no prediction, SAFE result: no prediction 2 2
P04406 GAPDH 42.0 III Cytosol;Plasma membrane NMF result: mitochondrial outer membrane, peroxisome, SAFE result: - 2 2
Q9UBU9 NXF1 50.3 III Nucleoplasm NMF result: miscellaneous, SAFE result: nuclear pore 2 2
Q08J23 NSUN2 52.7 III Nucleus NMF result: miscellaneous, SAFE result: - 2 2
Q71RC2 LARP4 130.6 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 2 2
Q14839 CHD4 61.8 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 2
Q13823 GNL2 111.9 VI Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 3
Q9BZE4 GTPBP4 76.2 V Nuclear membrane;Nucleoli NMF result: nucleolus, SAFE result: no prediction 1 3
O15381 NVL 49.2 III Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 3
Q9GZR7 DDX24 58.0 IV Cytosol;Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 3
Q9BQG0 MYBBP1A 54.4 IV Nucleoli;Vesicles NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 3
Q15397 PUM3 58.6 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 3
Q9NXF1 TEX10 94.1 V NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 3
P46087 NOP2 57.6 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q9GZR2 REXO4 52.4 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 2
O00571 DDX3X 146.2 VII Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 2
Q96GQ7 DDX27 62.3 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
O43159 RRP8 43.2 II Cytosol;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
P42696 RBM34 41.1 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q5TC82 RC3H1 62.0 IV Cytosol;Plasma membrane NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 2
Q9H8H2 DDX31 40.8 II Golgi apparatus;Nucleoli;Vesicles NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
O60287 URB1 9.2 I Nucleoli fibrillar center NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 2
Q7L2J0 MEPCE 53.8 III Cell Junctions;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 2
O95793 STAU1 111.0 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 2
Q15365 PCBP1 48.6 III Cytoplasmic bodies;Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 2
P67809 YBX1 148.5 VII Cytosol;Vesicles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 2
Q8NDF8 TENT4B 47.1 III NMF result: no prediction, SAFE result: no prediction 1 2
O75683 SURF6 56.6 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q92522 H1FX 41.6 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: no prediction 1 2
Q6PK04 CCDC137 59.7 V Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q5SSJ5 HP1BP3 50.5 III Nuclear speckles NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 2
Q2TB10 ZNF800 49.2 III Cytosol;Nucleoli NMF result: no prediction, SAFE result: no prediction 1 2
Q4G0J3 LARP7 54.3 IV Cytosol;Nucleoplasm NMF result: nucleolus, SAFE result: paraspeckles 1 2
Q9NZM5 NOP53 89.6 V Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q9NX58 LYAR 25.6 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q9H7B2 RPF2 69.1 V Nucleoli;Nucleus NMF result: miscellaneous, SAFE result: - 1 2
Q8WTT2 NOC3L 66.5 V Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q9NY93 DDX56 51.2 III NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 2
Q8IY81 FTSJ3 69.4 V Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q8TDN6 BRIX1 58.0 IV Nucleoli NMF result: miscellaneous, SAFE result: no prediction 1 2
P17096 HMGA1 45.8 III Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 2
Q9NW13 RBM28 49.3 III Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
Q9Y3I0 RTCB 54.9 IV Cytosol;Nucleoplasm;Vesicles NMF result: miscellaneous, SAFE result: - 1 1
Q9Y262 EIF3L 193.3 VII Nucleoli;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
P07814 EPRS 29.5 II Cytosol NMF result: actin cytoskeleton, cytosol, SAFE result: cell junction, plasma membrane 1 1
Q9NWT1 PAK1IP1 49.1 III Nucleoli;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q13283 G3BP1 220.8 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P62314 SNRPD1 54.6 IV NMF result: nuclear body, SAFE result: spliceosomal complex I 1 1
Q12906 ILF3 48.8 III Mitochondria;Nucleoli;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8IWS0 PHF6 50.6 III Nucleoli;Nucleus NMF result: nucleoplasm, SAFE result: - 1 1
Q5JTH9 RRP12 53.2 III Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q6PKG0 LARP1 253.4 VII Cytosol;Endoplasmic reticulum;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q8TAD8 SNIP1 40.9 II Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q9NVU7 SDAD1 103.6 VI Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q9H0A0 NAT10 55.7 IV Midbody;Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q8TDD1 DDX54 67.3 V Golgi apparatus;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P60842 EIF4A1 96.8 VI Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
P63241 EIF5A 53.2 III Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q1ED39 KNOP1 38.4 II Cytosol;Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q13610 PWP1 44.9 II Golgi apparatus;Nucleoli NMF result: no prediction, SAFE result: no prediction 1 1
Q00610 CLTC 33.4 II Cytosol;Mitotic spindle;Vesicles NMF result: actin cytoskeleton, cytosol, SAFE result: no prediction 1 1
Q03701 CEBPZ 52.3 III Nucleus;Vesicles NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P22626 HNRNPA2B1 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9BQ67 GRWD1 42.3 II Nucleoli;Nucleus NMF result: plasma membrane, SAFE result: - 1 1
P78344 EIF4G2 200.0 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q12873 CHD3 52.4 IV Microtubule organizing center;Nucleoli;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q13148 TARDBP 49.3 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O14646 CHD1 42.9 II Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
O00425 IGF2BP3 149.8 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
O43809 NUDT21 41.6 II Nuclear bodies NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9UNQ2 DIMT1 51.1 III Cytosol;Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
P63244 RACK1 43.3 III Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P27694 RPA1 45.5 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q9NRX1 PNO1 54.2 IV Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q00325 SLC25A3 44.7 II Mitochondria NMF result: plasma membrane, SAFE result: - 1 1
Q92615 LARP4B 233.7 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q92499 DDX1 74.7 V Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q9H6F5 CCDC86 98.8 VI Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P46013 MKI67 62.1 V Nuclear bodies;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
P31943 HNRNPH1 40.8 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8WUA2 PPIL4 48.0 III Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q9NVV4 MTPAP 50.7 III Mitochondria NMF result: mitochondrial matrix, SAFE result: mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix 1 1
Q9BYG3 NIFK 58.9 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P06733 ENO1 36.6 III Cytosol;Plasma membrane NMF result: miscellaneous, SAFE result: - 1 1
P09429 HMGB1 49.8 III Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
O95639 CPSF4 36.9 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
O96028 NSD2 41.7 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q9UHA3 RSL24D1 62.1 IV Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q12986 NFX1 77.5 V Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P17987 TCP1 45.1 III NMF result: miscellaneous, SAFE result: chaperonin-containing T-complex, prefoldin complex 1 1
O75821 EIF3G 105.9 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
O15372 EIF3H 64.3 IV Cytosol NMF result: centrosome, SAFE result: - 1 1
Q9Y3C1 NOP16 60.0 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q9H7N4 SCAF1 31.3 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q01780 EXOSC10 58.1 IV Cytosol;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q8TED0 UTP15 46.7 III Endoplasmic reticulum;Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q96ME7 ZNF512 45.2 III Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q6P158 DHX57 78.3 VI Cytosol;Intermediate filaments;Microtubules;Nucleoli NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9UGY1 NOL12 73.1 V Nucleoli;Nucleus;Vesicles NMF result: no prediction, SAFE result: no prediction 1 1
Q01844 EWSR1 36.3 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
P11021 HSPA5 48.9 III Cytosol NMF result: ER lumen, SAFE result: ER lumen 1 1
P51532 SMARCA4 51.3 III Nucleoplasm NMF result: nucleoplasm, SAFE result: Arp2/3 protein complex 1 1
O14776 TCERG1 40.9 II Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q8NC51 SERBP1 213.4 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9BXP5 SRRT 44.7 II Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 1 1
Q14103 HNRNPD 43.1 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q07955 SRSF1 41.6 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P08238 HSP90AB1 46.0 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
P09874 PARP1 45.3 II Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q16630 CPSF6 33.9 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P11387 TOP1 48.2 III Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P26599 PTBP1 46.5 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13310 PABPC4 147.7 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P14618 PKM 44.0 III Cytosol NMF result: miscellaneous, SAFE result: no prediction 1 1
P09651 HNRNPA1 43.1 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
O60264 SMARCA5 34.8 II Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
P16989 YBX3 137.7 VII Cytosol NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q8N8A6 DDX51 25.7 II Cytosol;Nucleoli;Nucleus NMF result: nucleoplasm, SAFE result: - 1 1
P05198 EIF2S1 98.9 VI Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: - 1 1
Q15029 EFTUD2 45.5 III Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
Q14980 NUMA1 47.8 III Nucleoplasm NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q9HCE1 MOV10 221.0 VII Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
Q86VM9 ZC3H18 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O94906 PRPF6 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: spliceosomal complex I 1 1
Q8N3Z6 ZCCHC7 46.0 III Cytosol;Nucleoli NMF result: no prediction, SAFE result: no prediction 1 1
Q9BZZ5 API5 69.0 V Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q14152 EIF3A 198.2 VII Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9BYW2 SETD2 28.3 II Cytosol;Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q7KZF4 SND1 245.8 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
P52272 HNRNPM 46.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P68104 EEF1A1 42.8 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
Q9BQ39 DDX50 23.3 II Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
P26368 U2AF2 37.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: - 1 1
P35637 FUS 37.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O15226 NKRF 47.5 III Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
O43709 BUD23 53.4 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q14694 USP10 192.3 VII Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9H0S4 DDX47 49.7 III Nucleoli NMF result: miscellaneous, SAFE result: - 1 1
O43143 DHX15 35.8 II Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
P07900 HSP90AA1 48.1 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
Q13151 HNRNPA0 43.7 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O15260 SURF4 38.5 II NMF result: mitochondrial outer membrane, peroxisome, SAFE result: no prediction 1 1
Q9Y5B9 SUPT16H 12.0 I Nucleoli fibrillar center;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P08621 SNRNP70 32.2 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q9Y388 RBMX2 39.8 II Nuclear membrane;Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P12270 TPR 53.6 IV Nuclear membrane NMF result: no prediction, SAFE result: no prediction 1 1
O43390 HNRNPR 48.0 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1