UPF1


UniProt Accession Q92900 UniProt 🔗
Synonyms KIAA0221, RENT1
UniProt protein names Regulator of nonsense transcripts 1;
ATP-dependent helicase RENT1;
Nonsense mRNA reducing factor 1;
Up-frameshift suppressor 1 homolog
Peak binding time (min) 158.9
Cluster VII
Cluster membership (corr) 0.997
Peak broadness (1 / std of log2 intensities) 1.32
Cluster expected from GO VII
Subcellular localization (Human Protein Atlas) Nucleoplasm
Subcellular localization (Human Cell Map) NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule
RMSE (expected - observed) 0.04
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics


Gene Ontology based expectation (GO 2021-09-01)


Protein interactors of UPF1 in mRNP (BioGRID)


Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
O95793 STAU1 111.0 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 3 5
P11940 PABPC1 124.3 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 3 4
Q9BZI7 UPF3B 64.9 V Cytosol;Nucleoli;Nucleus NMF result: plasma membrane, SAFE result: - 2 8
Q9HCE1 MOV10 221.0 VII Cytosol NMF result: no prediction, SAFE result: no prediction 2 2
Q13283 G3BP1 220.8 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 2 2
O60506 SYNCRIP 71.4 V Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles 2 2
Q7Z2W4 ZC3HAV1 211.8 VII Cytosol;Golgi apparatus NMF result: nuclear outer membrane-ER membrane network, SAFE result: nuclear outer membrane-ER membrane network 2 2
Q5TC82 RC3H1 62.0 IV Cytosol;Plasma membrane NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 2 2
Q14152 EIF3A 198.2 VII Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 2 1
P55265 ADAR 48.0 III Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 2 1
P38919 EIF4A3 67.1 V Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 3
Q9Y5S9 RBM8A 77.3 V Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 3
Q9BYG3 NIFK 58.9 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 2
P09651 HNRNPA1 43.1 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 2
P08621 SNRNP70 32.2 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 2
Q86VM9 ZC3H18 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 2
Q12905 ILF2 48.0 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 2
Q13595 TRA2A 42.2 II Nucleoli;Vesicles NMF result: no prediction, SAFE result: no prediction 1 2
Q14157 UBAP2L 212.4 VII Cytosol;Nuclear speckles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9UKV8 AGO2 103.6 VI Cell Junctions;Nucleoplasm NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched 1 1
Q13573 SNW1 51.8 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q15287 RNPS1 58.0 IV Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P98179 RBM3 43.6 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q96SI9 STRBP 47.4 III NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9NZI8 IGF2BP1 143.9 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q15646 OASL 104.1 VI Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P60842 EIF4A1 96.8 VI Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
P29558 RBMS1 107.1 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9NZM5 NOP53 89.6 V Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q9BQ67 GRWD1 42.3 II Nucleoli;Nucleus NMF result: plasma membrane, SAFE result: - 1 1
Q13148 TARDBP 49.3 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9NPD3 EXOSC4 57.8 IV Cytosol;Intermediate filaments NMF result: no prediction, SAFE result: no prediction 1 1
Q9NZB2 FAM120A 158.5 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
O60293 ZFC3H1 51.3 III Intermediate filaments;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q92615 LARP4B 233.7 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q15717 ELAVL1 46.3 III Cytosol;Nucleoli;Nucleus NMF result: miscellaneous, SAFE result: paraspeckles 1 1
Q9Y6M1 IGF2BP2 159.3 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q8ND56 LSM14A 138.4 VII Cytoplasmic bodies;Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q99459 CDC5L 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P61326 MAGOH 70.2 V Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
P51116 FXR2 171.1 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q12986 NFX1 77.5 V Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q96I24 FUBP3 51.8 III Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles 1 1
O00571 DDX3X 146.2 VII Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q00341 HDLBP 171.5 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q14671 PUM1 104.1 VI Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P11142 HSPA8 45.1 III Nucleoplasm;Vesicles NMF result: miscellaneous, SAFE result: no prediction 1 1
Q01780 EXOSC10 58.1 IV Cytosol;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q01804 OTUD4 99.3 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q00839 HNRNPU 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q01844 EWSR1 36.3 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
P51532 SMARCA4 51.3 III Nucleoplasm NMF result: nucleoplasm, SAFE result: Arp2/3 protein complex 1 1
Q92879 CELF1 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O95985 TOP3B 72.2 V Vesicles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9BYJ9 YTHDF1 222.1 VII NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q99700 ATXN2 116.5 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P51114 FXR1 172.6 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q14444 CAPRIN1 229.7 VII NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q7Z739 YTHDF3 111.3 VI Cytosol;Nuclear membrane;Nuclear speckles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q8TBF4 ZCRB1 36.7 II NMF result: no prediction, SAFE result: no prediction 1 1
O75534 CSDE1 122.4 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P05198 EIF2S1 98.9 VI Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: - 1 1
Q06787 FMR1 176.8 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q15029 EFTUD2 45.5 III Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
P48634 PRRC2A 106.7 VI Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P17844 DDX5 40.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
A0AV96 RBM47 58.8 IV Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9H000 MKRN2 65.9 V Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9Y5A9 YTHDF2 111.0 VI Cytoplasmic bodies;Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9NUL3 STAU2 140.6 VII Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
P52298 NCBP2 45.8 III Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P26368 U2AF2 37.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: - 1 1
Q9H7E2 TDRD3 89.3 VI Cytosol;Golgi apparatus;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9BRZ2 TRIM56 74.3 V Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: - 1 1
Q17RY0 CPEB4 87.8 VI Golgi apparatus;Nucleoplasm;Vesicles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q14694 USP10 192.3 VII Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q7Z417 NUFIP2 124.8 VI Cytosol;Nuclear bodies;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q15365 PCBP1 48.6 III Cytoplasmic bodies;Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
Q5VT52 RPRD2 8.3 I Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
Q9NX05 FAM120C 233.5 VII Nuclear speckles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q9C0B0 UNK 88.4 VI Cytoplasmic bodies;Cytosol NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched 1 1
O43390 HNRNPR 48.0 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1