POLR2A
| UniProt Accession | P24928 UniProt 🔗 |
|---|---|
| Synonyms | POLR2 |
| UniProt protein names | DNA-directed RNA polymerase II subunit RPB1;DNA-directed RNA polymerase II subunit A;DNA-directed RNA polymerase III largest subunit;RNA-directed RNA polymerase II subunit RPB1 |
| Peak binding time (min) | 0.0 |
| Cluster | I |
| Cluster membership (corr) | 0.993 |
| Peak broadness (1 / std of log2 intensities) | 0.79 |
| Cluster expected from GO | I |
| Subcellular localization (Human Protein Atlas) | Nucleoplasm |
| Subcellular localization (Human Cell Map) | NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm |
| RMSE (expected - observed) | 0.11 |
| Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of POLR2A in mRNP (BioGRID)
| Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
|---|---|---|---|---|---|---|---|
| O00267 | SUPT5H | 0.0 | I | Nucleoplasm | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 5 | 10 |
| P51532 | SMARCA4 | 51.3 | III | Nucleoplasm | NMF result: nucleoplasm, SAFE result: Arp2/3 protein complex | 4 | 6 |
| Q9H7E2 | TDRD3 | 89.3 | VI | Cytosol;Golgi apparatus;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 4 | 2 |
| P30876 | POLR2B | 0.0 | I | Nucleoplasm | NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm | 3 | 4 |
| Q00839 | HNRNPU | 42.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 3 | 4 |
| Q12996 | CSTF3 | 9.6 | I | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 3 | 3 |
| O14776 | TCERG1 | 40.9 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 3 | 2 |
| Q7KZ85 | SUPT6H | 0.0 | I | Cytosol;Nucleoplasm;Plasma membrane | NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm | 2 | 3 |
| Q05048 | CSTF1 | 22.4 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 2 | 3 |
| Q14241 | ELOA | 41.3 | II | Nuclear speckles | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 2 | 2 |
| Q9BYW2 | SETD2 | 28.3 | II | Cytosol;Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 2 |
| Q9H0D6 | XRN2 | 41.9 | II | Nucleoli;Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
| Q9UIG0 | BAZ1B | 44.3 | II | Nuclear bodies | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 2 | 1 |
| O60828 | PQBP1 | 38.7 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 2 | 1 |
| P33240 | CSTF2 | 23.7 | II | Nuclear bodies;Nucleoplasm | NMF result: nuclear body, SAFE result: no prediction | 2 | 1 |
| Q7KZF4 | SND1 | 245.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 2 | 1 |
| Q08211 | DHX9 | 50.2 | III | Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 4 |
| P17844 | DDX5 | 40.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 2 |
| Q01844 | EWSR1 | 36.3 | II | Nucleoli;Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q5T200 | ZC3H13 | 38.4 | II | Actin filaments;Nuclear membrane | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9UBU9 | NXF1 | 50.3 | III | Nucleoplasm | NMF result: miscellaneous, SAFE result: nuclear pore | 1 | 1 |
| P27694 | RPA1 | 45.5 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P78347 | GTF2I | 49.8 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9UKV8 | AGO2 | 103.6 | VI | Cell Junctions;Nucleoplasm | NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched | 1 | 1 |
| Q15717 | ELAVL1 | 46.3 | III | Cytosol;Nucleoli;Nucleus | NMF result: miscellaneous, SAFE result: paraspeckles | 1 | 1 |
| P62314 | SNRPD1 | 54.6 | IV | NMF result: nuclear body, SAFE result: spliceosomal complex I | 1 | 1 | |
| Q12906 | ILF3 | 48.8 | III | Mitochondria;Nucleoli;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9BXP5 | SRRT | 44.7 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: no prediction | 1 | 1 |
| P27816 | MAP4 | 62.7 | V | Cytosol;Microtubules;Plasma membrane | NMF result: microtubule cytoskeleton, SAFE result: microtubule cytoskeleton | 1 | 1 |
| Q14103 | HNRNPD | 43.1 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P52298 | NCBP2 | 45.8 | III | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P68104 | EEF1A1 | 42.8 | III | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P26368 | U2AF2 | 37.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: - | 1 | 1 |
| P35637 | FUS | 37.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q92804 | TAF15 | 35.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q8TAD8 | SNIP1 | 40.9 | II | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P09012 | SNRPA | 44.9 | III | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P09429 | HMGB1 | 49.8 | III | Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q69YN4 | VIRMA | 0.0 | I | Nuclear bodies;Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q01130 | SRSF2 | 41.6 | II | Cytosol;Nucleus | NMF result: chromatin, SAFE result: - | 1 | 1 |
| P53999 | SUB1 | 43.3 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q86V81 | ALYREF | 71.2 | V | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 | |
| Q15029 | EFTUD2 | 45.5 | III | Cytosol;Nucleoplasm | NMF result: miscellaneous, SAFE result: spliceosomal complex I | 1 | 1 |
| Q08945 | SSRP1 | 0.0 | I | Cytosol;Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q5BKZ1 | ZNF326 | 44.1 | II | Golgi apparatus;Nucleoplasm;Vesicles | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| O43719 | HTATSF1 | 54.0 | IV | Nucleoplasm | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q92841 | DDX17 | 39.2 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9HCE1 | MOV10 | 221.0 | VII | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P08621 | SNRNP70 | 32.2 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9C0B0 | UNK | 88.4 | VI | Cytoplasmic bodies;Cytosol | NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched | 1 | 1 |
| Q96PU8 | QKI | 47.1 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| O43390 | HNRNPR | 48.0 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |