NCL
UniProt Accession | P19338 UniProt 🔗 |
---|---|
Synonyms | |
UniProt protein names | Nucleolin;Protein C23 |
Peak binding time (min) | 27.1 |
Cluster | II |
Cluster membership (corr) | 0.993 |
Peak broadness (1 / std of log2 intensities) | 0.95 |
Cluster expected from GO | III |
Subcellular localization (Human Protein Atlas) | Nucleoli;Nucleus |
Subcellular localization (Human Cell Map) | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus |
RMSE (expected - observed) | 0.32 |
Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of NCL in mRNP (BioGRID)
Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
---|---|---|---|---|---|---|---|
P06748 | NPM1 | 56.1 | IV | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 4 | 6 |
O95793 | STAU1 | 111.0 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 3 | 4 |
P11387 | TOP1 | 48.2 | III | Nucleoli fibrillar center;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 3 | 3 |
P12956 | XRCC6 | 47.9 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 3 | 2 |
Q9UQ80 | PA2G4 | 53.8 | IV | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 2 | 3 |
Q12906 | ILF3 | 48.8 | III | Mitochondria;Nucleoli;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
Q08211 | DHX9 | 50.2 | III | Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
Q14103 | HNRNPD | 43.1 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
P05455 | SSB | 45.1 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 2 | 2 |
Q01780 | EXOSC10 | 58.1 | IV | Cytosol;Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 2 | 1 |
Q7Z2W4 | ZC3HAV1 | 211.8 | VII | Cytosol;Golgi apparatus | NMF result: nuclear outer membrane-ER membrane network, SAFE result: nuclear outer membrane-ER membrane network | 2 | 1 |
Q86V81 | ALYREF | 71.2 | V | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 2 | 1 | |
Q9UBU9 | NXF1 | 50.3 | III | Nucleoplasm | NMF result: miscellaneous, SAFE result: nuclear pore | 2 | 1 |
P27695 | APEX1 | 53.4 | III | Nucleus | NMF result: no prediction, SAFE result: no prediction | 2 | 1 |
Q12986 | NFX1 | 77.5 | V | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 2 |
Q14839 | CHD4 | 61.8 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 2 |
Q9BQG0 | MYBBP1A | 54.4 | IV | Nucleoli;Vesicles | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 2 |
Q5TC82 | RC3H1 | 62.0 | IV | Cytosol;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 2 |
Q9Y262 | EIF3L | 193.3 | VII | Nucleoli;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 2 |
P26368 | U2AF2 | 37.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: - | 1 | 2 |
Q4G0J3 | LARP7 | 54.3 | IV | Cytosol;Nucleoplasm | NMF result: nucleolus, SAFE result: paraspeckles | 1 | 2 |
P61978 | HNRNPK | 42.6 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 2 |
Q8TCS8 | PNPT1 | 53.6 | IV | Mitochondria | NMF result: mitochondrial matrix, SAFE result: mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix | 1 | 1 |
P42285 | MTREX | 73.4 | V | Nucleus | NMF result: chromatin, SAFE result: - | 1 | 1 |
Q96SB4 | SRPK1 | 52.0 | IV | Cytosol;Nucleus;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
Q06265 | EXOSC9 | 54.5 | IV | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
P30876 | POLR2B | 0.0 | I | Nucleoplasm | NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm | 1 | 1 |
P62314 | SNRPD1 | 54.6 | IV | NMF result: nuclear body, SAFE result: spliceosomal complex I | 1 | 1 | |
Q7RTV0 | PHF5A | 37.6 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q7KZ85 | SUPT6H | 0.0 | I | Cytosol;Nucleoplasm;Plasma membrane | NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm | 1 | 1 |
Q15427 | SF3B4 | 38.3 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q9H0A0 | NAT10 | 55.7 | IV | Midbody;Nucleoli | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
Q9BZE4 | GTPBP4 | 76.2 | V | Nuclear membrane;Nucleoli | NMF result: nucleolus, SAFE result: no prediction | 1 | 1 |
Q9NZI8 | IGF2BP1 | 143.9 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
Q13610 | PWP1 | 44.9 | II | Golgi apparatus;Nucleoli | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q8TDN6 | BRIX1 | 58.0 | IV | Nucleoli | NMF result: miscellaneous, SAFE result: no prediction | 1 | 1 |
Q9NZM5 | NOP53 | 89.6 | V | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
Q9NVP1 | DDX18 | 49.1 | III | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
Q9Y2P8 | RCL1 | 58.2 | IV | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q9BQ67 | GRWD1 | 42.3 | II | Nucleoli;Nucleus | NMF result: plasma membrane, SAFE result: - | 1 | 1 |
Q12873 | CHD3 | 52.4 | IV | Microtubule organizing center;Nucleoli;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
P84103 | SRSF3 | 43.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: no prediction | 1 | 1 |
Q13148 | TARDBP | 49.3 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
Q9NPD3 | EXOSC4 | 57.8 | IV | Cytosol;Intermediate filaments | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q9NX58 | LYAR | 25.6 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
P27694 | RPA1 | 45.5 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
Q96QD9 | FYTTD1 | 75.0 | V | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q9H7B2 | RPF2 | 69.1 | V | Nucleoli;Nucleus | NMF result: miscellaneous, SAFE result: - | 1 | 1 |
Q15717 | ELAVL1 | 46.3 | III | Cytosol;Nucleoli;Nucleus | NMF result: miscellaneous, SAFE result: paraspeckles | 1 | 1 |
Q99459 | CDC5L | 49.2 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
P31943 | HNRNPH1 | 40.8 | II | Cytosol;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
Q9NVV4 | MTPAP | 50.7 | III | Mitochondria | NMF result: mitochondrial matrix, SAFE result: mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix | 1 | 1 |
Q8IY81 | FTSJ3 | 69.4 | V | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
Q9NR30 | DDX21 | 0.0 | I | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
P09429 | HMGB1 | 49.8 | III | Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
Q9BTD8 | RBM42 | 40.1 | II | Cytosol;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
O96028 | NSD2 | 41.7 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
O75940 | SMNDC1 | 36.3 | II | Nuclear bodies;Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
O75821 | EIF3G | 105.9 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
Q9BVP2 | GNL3 | 68.1 | V | Nuclear bodies;Nucleoli | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
O00267 | SUPT5H | 0.0 | I | Nucleoplasm | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
O75643 | SNRNP200 | 42.7 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: spliceosomal complex I | 1 | 1 |
Q00839 | HNRNPU | 42.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
P17096 | HMGA1 | 45.8 | III | Nucleoli;Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
Q8IYB3 | SRRM1 | 39.4 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
O43395 | PRPF3 | 48.3 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
P51532 | SMARCA4 | 51.3 | III | Nucleoplasm | NMF result: nucleoplasm, SAFE result: Arp2/3 protein complex | 1 | 1 |
O43290 | SART1 | 39.6 | II | Golgi apparatus;Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
Q13243 | SRSF5 | 41.7 | II | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
P26599 | PTBP1 | 46.5 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
Q9UHX1 | PUF60 | 35.4 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
Q9GZR7 | DDX24 | 58.0 | IV | Cytosol;Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
P09651 | HNRNPA1 | 43.1 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
O60264 | SMARCA5 | 34.8 | II | Nucleoli fibrillar center;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |
Q06787 | FMR1 | 176.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
Q15029 | EFTUD2 | 45.5 | III | Cytosol;Nucleoplasm | NMF result: miscellaneous, SAFE result: spliceosomal complex I | 1 | 1 |
Q86VM9 | ZC3H18 | 39.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
P11940 | PABPC1 | 124.3 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
P67809 | YBX1 | 148.5 | VII | Cytosol;Vesicles | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
P33992 | MCM5 | 42.8 | III | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q9BZZ5 | API5 | 69.0 | V | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
Q14152 | EIF3A | 198.2 | VII | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
O15371 | EIF3D | 208.1 | VII | Cytosol | NMF result: miscellaneous, SAFE result: - | 1 | 1 |
Q14498 | RBM39 | 30.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: no prediction | 1 | 1 |
Q7L2E3 | DHX30 | 56.5 | IV | Cytosol;Mitochondria | NMF result: mitochondrial matrix, SAFE result: mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix | 1 | 1 |
Q9BRJ6 | C7orf50 | 51.1 | III | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q9BQ39 | DDX50 | 23.3 | II | Nucleoli | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
O15042 | U2SURP | 33.1 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
Q7L2J0 | MEPCE | 53.8 | III | Cell Junctions;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
Q92522 | H1FX | 41.6 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: no prediction | 1 | 1 |
Q12905 | ILF2 | 48.0 | III | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q08J23 | NSUN2 | 52.7 | III | Nucleus | NMF result: miscellaneous, SAFE result: - | 1 | 1 |
P37108 | SRP14 | 45.6 | III | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q9H0S4 | DDX47 | 49.7 | III | Nucleoli | NMF result: miscellaneous, SAFE result: - | 1 | 1 |
O43143 | DHX15 | 35.8 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
P07900 | HSP90AA1 | 48.1 | III | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
Q15365 | PCBP1 | 48.6 | III | Cytoplasmic bodies;Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
P08621 | SNRNP70 | 32.2 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
O15446 | CD3EAP | 0.0 | I | Mitochondria;Nucleoli fibrillar center;Nucleus | NMF result: nucleoplasm, SAFE result: no prediction | 1 | 1 |
Q9C0B0 | UNK | 88.4 | VI | Cytoplasmic bodies;Cytosol | NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched | 1 | 1 |
Q15061 | WDR43 | 34.7 | II | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 | |
O43390 | HNRNPR | 48.0 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |