SRPK1
| UniProt Accession | Q96SB4 UniProt 🔗 |
|---|---|
| Synonyms | |
| UniProt protein names | SRSF protein kinase 1;SFRS protein kinase 1;Serine/arginine-rich protein-specific kinase 1 |
| Peak binding time (min) | 52.0 |
| Cluster | IV |
| Cluster membership (corr) | 0.990 |
| Peak broadness (1 / std of log2 intensities) | 2.52 |
| Cluster expected from GO | IV |
| Subcellular localization (Human Protein Atlas) | Cytosol;Nucleus;Plasma membrane |
| Subcellular localization (Human Cell Map) | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction |
| RMSE (expected - observed) | 0.05 |
| Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of SRPK1 in mRNP (BioGRID)
| Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
|---|---|---|---|---|---|---|---|
| Q07955 | SRSF1 | 41.6 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 4 | 5 |
| P08621 | SNRNP70 | 32.2 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 3 | 4 |
| Q15287 | RNPS1 | 58.0 | IV | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 3 | 3 |
| Q96MU7 | YTHDC1 | 54.8 | IV | Nucleoplasm;Plasma membrane | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 3 | 1 |
| Q14562 | DHX8 | 46.2 | III | Nuclear bodies;Nucleoplasm | NMF result: nuclear body, SAFE result: spliceosomal complex II | 2 | 3 |
| Q9Y383 | LUC7L2 | 29.7 | II | Nucleus | NMF result: ER lumen, SAFE result: - | 2 | 3 |
| Q9NRR4 | DROSHA | 45.3 | III | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 2 | 3 | |
| Q66PJ3 | ARL6IP4 | 47.0 | III | NMF result: no prediction, SAFE result: no prediction | 2 | 3 | |
| Q9NQ29 | LUC7L | 43.6 | II | Mitochondria;Nucleus | NMF result: no prediction, SAFE result: no prediction | 2 | 3 |
| P07910 | HNRNPC | 47.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
| Q01130 | SRSF2 | 41.6 | II | Cytosol;Nucleus | NMF result: chromatin, SAFE result: - | 2 | 2 |
| Q9Y5S9 | RBM8A | 77.3 | V | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 2 | 1 |
| Q16629 | SRSF7 | 42.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 2 | 1 |
| Q14498 | RBM39 | 30.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: no prediction | 2 | 1 |
| Q9BRL6 | SRSF8 | 42.6 | II | Cytosol;Nucleus | NMF result: no prediction, SAFE result: no prediction | 2 | 1 |
| P26368 | U2AF2 | 37.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: - | 1 | 2 |
| Q15365 | PCBP1 | 48.6 | III | Cytoplasmic bodies;Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| Q9UKV3 | ACIN1 | 60.5 | IV | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 2 |
| Q9H307 | PNN | 64.6 | IV | Nuclear speckles | NMF result: nuclear body, SAFE result: spliceosomal complex II | 1 | 2 |
| Q9UQ35 | SRRM2 | 42.5 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 2 |
| P19338 | NCL | 27.1 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P17844 | DDX5 | 40.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q01844 | EWSR1 | 36.3 | II | Nucleoli;Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| O43809 | NUDT21 | 41.6 | II | Nuclear bodies | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q13247 | SRSF6 | 45.9 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: spliceosomal complex II | 1 | 1 |
| P43243 | MATR3 | 47.9 | III | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 | |
| Q9P2N5 | RBM27 | 49.2 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9BZZ5 | API5 | 69.0 | V | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| O43290 | SART1 | 39.6 | II | Golgi apparatus;Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q5TC82 | RC3H1 | 62.0 | IV | Cytosol;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| P18583 | SON | 43.3 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q8N5F7 | NKAP | 47.0 | III | Cytosol;Nucleoplasm | NMF result: nuclear body, SAFE result: spliceosomal complex II | 1 | 1 |
| P11388 | TOP2A | 49.6 | III | Nucleoli;Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q15717 | ELAVL1 | 46.3 | III | Cytosol;Nucleoli;Nucleus | NMF result: miscellaneous, SAFE result: paraspeckles | 1 | 1 |
| P27695 | APEX1 | 53.4 | III | Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q8IWX8 | CHERP | 23.2 | II | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 | |
| P52272 | HNRNPM | 46.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P46013 | MKI67 | 62.1 | V | Nuclear bodies;Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q12906 | ILF3 | 48.8 | III | Mitochondria;Nucleoli;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P46087 | NOP2 | 57.6 | IV | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P31943 | HNRNPH1 | 40.8 | II | Cytosol;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P38919 | EIF4A3 | 67.1 | V | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P61326 | MAGOH | 70.2 | V | Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P35637 | FUS | 37.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P52292 | KPNA2 | 53.6 | V | Cytosol;Nucleoplasm | NMF result: nucleoplasm, SAFE result: - | 1 | 1 |
| Q6PKG0 | LARP1 | 253.4 | VII | Cytosol;Endoplasmic reticulum;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| O95793 | STAU1 | 111.0 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| O95218 | ZRANB2 | 54.2 | III | Nucleus | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9BU76 | MMTAG2 | 41.6 | II | Cytosol;Nuclear speckles;Plasma membrane | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9H0A0 | NAT10 | 55.7 | IV | Midbody;Nucleoli | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9Y2W1 | THRAP3 | 37.2 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q12986 | NFX1 | 77.5 | V | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q12874 | SF3A3 | 37.2 | II | Nucleoplasm | NMF result: chromatin, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q86V81 | ALYREF | 71.2 | V | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 | |
| P09651 | HNRNPA1 | 43.1 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q4G0J3 | LARP7 | 54.3 | IV | Cytosol;Nucleoplasm | NMF result: nucleolus, SAFE result: paraspeckles | 1 | 1 |
| Q9H0S4 | DDX47 | 49.7 | III | Nucleoli | NMF result: miscellaneous, SAFE result: - | 1 | 1 |
| P16989 | YBX3 | 137.7 | VII | Cytosol | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9Y3C1 | NOP16 | 60.0 | IV | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9NYF8 | BCLAF1 | 37.5 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q15029 | EFTUD2 | 45.5 | III | Cytosol;Nucleoplasm | NMF result: miscellaneous, SAFE result: spliceosomal complex I | 1 | 1 |
| P07900 | HSP90AA1 | 48.1 | III | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| O95232 | LUC7L3 | 37.8 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: spliceosomal complex II | 1 | 1 |
| Q13427 | PPIG | 53.4 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: spliceosomal complex II | 1 | 1 |
| Q08945 | SSRP1 | 0.0 | I | Cytosol;Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9BRP8 | PYM1 | 247.2 | VII | Cell Junctions;Cytosol;Nucleoli;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: - | 1 | 1 |
| Q15424 | SAFB | 45.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q86VM9 | ZC3H18 | 39.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P11940 | PABPC1 | 124.3 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q13148 | TARDBP | 49.3 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P62995 | TRA2B | 42.0 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q14839 | CHD4 | 61.8 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9Y3Y2 | CHTOP | 75.6 | V | Nuclear speckles | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9BQ67 | GRWD1 | 42.3 | II | Nucleoli;Nucleus | NMF result: plasma membrane, SAFE result: - | 1 | 1 |
| P84103 | SRSF3 | 43.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: no prediction | 1 | 1 |