HMGB1

UniProt Accession P09429 UniProt 🔗
Synonyms HMG1
UniProt protein names High mobility group protein B1;
High mobility group protein 1
Peak binding time (min) 49.8
Cluster III
Cluster membership (corr) 0.998
Peak broadness (1 / std of log2 intensities) 1.46
Cluster expected from GO III
Subcellular localization (Human Protein Atlas) Nucleus
Subcellular localization (Human Cell Map) NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm
RMSE (expected - observed) 0.05
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of HMGB1 in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
P09874 PARP1 45.3 II Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 3 2
Q08945 SSRP1 0.0 I Cytosol;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 3
Q9Y5B9 SUPT16H 12.0 I Nucleoli fibrillar center;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 2
P11142 HSPA8 45.1 III Nucleoplasm;Vesicles NMF result: miscellaneous, SAFE result: no prediction 2 2
P61978 HNRNPK 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
P19338 NCL 27.1 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q01844 EWSR1 36.3 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q16629 SRSF7 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P11021 HSPA5 48.9 III Cytosol NMF result: ER lumen, SAFE result: ER lumen 1 1
Q9H307 PNN 64.6 IV Nuclear speckles NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
P51532 SMARCA4 51.3 III Nucleoplasm NMF result: nucleoplasm, SAFE result: Arp2/3 protein complex 1 1
Q14151 SAFB2 45.8 III Nuclear bodies;Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q13247 SRSF6 45.9 II Nuclear speckles NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
Q96EY7 PTCD3 77.4 V Mitochondria NMF result: mitochondrial matrix, SAFE result: mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix 1 1
Q6PJT7 ZC3H14 65.7 IV Nuclear speckles NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
Q14498 RBM39 30.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 1 1
Q9UQ35 SRRM2 42.5 III Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P11388 TOP2A 49.6 III Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P30876 POLR2B 0.0 I Nucleoplasm NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm 1 1
P24928 POLR2A 0.0 I Nucleoplasm NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm 1 1
P06748 NPM1 56.1 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q7KZ85 SUPT6H 0.0 I Cytosol;Nucleoplasm;Plasma membrane NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm 1 1
Q9BXP5 SRRT 44.7 II Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 1 1
P46087 NOP2 57.6 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q07955 SRSF1 41.6 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q13573 SNW1 51.8 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9NWH9 SLTM 42.7 II Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P38919 EIF4A3 67.1 V Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q15287 RNPS1 58.0 IV Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P26368 U2AF2 37.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: - 1 1
Q6PKG0 LARP1 253.4 VII Cytosol;Endoplasmic reticulum;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q13595 TRA2A 42.2 II Nucleoli;Vesicles NMF result: no prediction, SAFE result: no prediction 1 1
P30414 NKTR 48.4 III Cytosol;Nucleoplasm;Plasma membrane NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q13243 SRSF5 41.7 II Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
O95218 ZRANB2 54.2 III Nucleus NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q6UN15 FIP1L1 19.3 I Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9H0A0 NAT10 55.7 IV Midbody;Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9Y2W1 THRAP3 37.2 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P07910 HNRNPC 47.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O96028 NSD2 41.7 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q5SSJ5 HP1BP3 50.5 III Nuclear speckles NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P51991 HNRNPA3 43.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O60264 SMARCA5 34.8 II Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q4G0J3 LARP7 54.3 IV Cytosol;Nucleoplasm NMF result: nucleolus, SAFE result: paraspeckles 1 1
Q8IX12 CCAR1 35.1 II Golgi apparatus;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9NYF8 BCLAF1 37.5 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q15029 EFTUD2 45.5 III Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
O15347 HMGB3 46.3 III Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q9BVP2 GNL3 68.1 V Nuclear bodies;Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
P38159 RBMX 44.4 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8NEJ9 NGDN 55.6 IV Mitochondria;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
O75494 SRSF10 46.3 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q5BKZ1 ZNF326 44.1 II Golgi apparatus;Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q14980 NUMA1 47.8 III Nucleoplasm NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q15424 SAFB 45.0 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q9UKV3 ACIN1 60.5 IV Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q86VM9 ZC3H18 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9BY77 POLDIP3 74.6 V Cytoplasmic bodies;Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
O75533 SF3B1 40.9 II Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
O75643 SNRNP200 42.7 II Nucleoplasm NMF result: nuclear body, SAFE result: spliceosomal complex I 1 1
P62995 TRA2B 42.0 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q00839 HNRNPU 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P17096 HMGA1 45.8 III Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q02880 TOP2B 50.4 III Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9Y3Y2 CHTOP 75.6 V Nuclear speckles NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P84103 SRSF3 43.0 II Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 1 1