PUF60
| UniProt Accession | Q9UHX1 UniProt 🔗 |
|---|---|
| Synonyms | FIR, ROBPI, SIAHBP1 |
| UniProt protein names | Poly(U)-binding-splicing factor PUF60;60 kDa poly(U)-binding-splicing factor;FUSE-binding protein-interacting repressor;Ro-binding protein 1;Siah-binding protein 1 |
| Peak binding time (min) | 35.4 |
| Cluster | II |
| Cluster membership (corr) | 0.999 |
| Peak broadness (1 / std of log2 intensities) | 1.01 |
| Cluster expected from GO | II |
| Subcellular localization (Human Protein Atlas) | Nucleoplasm |
| Subcellular localization (Human Cell Map) | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm |
| RMSE (expected - observed) | 0.16 |
| Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of PUF60 in mRNP (BioGRID)
| Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
|---|---|---|---|---|---|---|---|
| P26368 | U2AF2 | 37.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: - | 3 | 7 |
| Q05519 | SRSF11 | 52.0 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 3 | 4 |
| O75533 | SF3B1 | 40.9 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 2 | 2 |
| Q9BQ52 | ELAC2 | 60.6 | III | Nucleoplasm | NMF result: mitochondrial matrix, SAFE result: mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix | 2 | 2 |
| Q12874 | SF3A3 | 37.2 | II | Nucleoplasm | NMF result: chromatin, SAFE result: splicing speckles, nucleolus | 2 | 2 |
| P07910 | HNRNPC | 47.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
| Q96AE4 | FUBP1 | 36.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
| Q15365 | PCBP1 | 48.6 | III | Cytoplasmic bodies;Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 2 | 1 |
| Q15428 | SF3A2 | 31.3 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| Q7Z5Q1 | CPEB2 | 111.4 | VI | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q01844 | EWSR1 | 36.3 | II | Nucleoli;Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| O00425 | IGF2BP3 | 149.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P19338 | NCL | 27.1 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q15637 | SF1 | 40.9 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P43243 | MATR3 | 47.9 | III | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 | |
| Q9Y3B4 | SF3B6 | 36.0 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P49756 | RBM25 | 34.8 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P05455 | SSB | 45.1 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| O43670 | ZNF207 | 29.7 | II | Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q92945 | KHSRP | 37.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q5TC82 | RC3H1 | 62.0 | IV | Cytosol;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| P18583 | SON | 43.3 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9UQ35 | SRRM2 | 42.5 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q13283 | G3BP1 | 220.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9Y6M1 | IGF2BP2 | 159.3 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| P52272 | HNRNPM | 46.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P68104 | EEF1A1 | 42.8 | III | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P31942 | HNRNPH3 | 39.3 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q13573 | SNW1 | 51.8 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q15287 | RNPS1 | 58.0 | IV | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q7L2J0 | MEPCE | 53.8 | III | Cell Junctions;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| O95793 | STAU1 | 111.0 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q16630 | CPSF6 | 33.9 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q12905 | ILF2 | 48.0 | III | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9Y2W1 | THRAP3 | 37.2 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P52597 | HNRNPF | 42.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9NZI8 | IGF2BP1 | 143.9 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q13310 | PABPC4 | 147.7 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P51991 | HNRNPA3 | 43.2 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P09651 | HNRNPA1 | 43.1 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| O00571 | DDX3X | 146.2 | VII | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q4G0J3 | LARP7 | 54.3 | IV | Cytosol;Nucleoplasm | NMF result: nucleolus, SAFE result: paraspeckles | 1 | 1 |
| Q15029 | EFTUD2 | 45.5 | III | Cytosol;Nucleoplasm | NMF result: miscellaneous, SAFE result: spliceosomal complex I | 1 | 1 |
| O75400 | PRPF40A | 39.8 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9HCE1 | MOV10 | 221.0 | VII | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P14866 | HNRNPL | 42.6 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9UKA9 | PTBP2 | 44.3 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P08621 | SNRNP70 | 32.2 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| O60506 | SYNCRIP | 71.4 | V | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles | 1 | 1 |
| P11940 | PABPC1 | 124.3 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q15056 | EIF4H | 115.6 | VI | Cytosol;Nuclear bodies;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: - | 1 | 1 |
| Q14839 | CHD4 | 61.8 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q8IYB3 | SRRM1 | 39.4 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q12873 | CHD3 | 52.4 | IV | Microtubule organizing center;Nucleoli;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |