XRCC6

UniProt Accession P12956 UniProt 🔗
Synonyms G22P1
UniProt protein names X-ray repair cross-complementing protein 6;
5'-deoxyribose-5-phosphate lyase Ku70;
70 kDa subunit of Ku antigen;
ATP-dependent DNA helicase 2 subunit 1;
ATP-dependent DNA helicase II 70 kDa subunit;
CTC box-binding factor 75 kDa subunit;
DNA repair protein XRCC6;
Lupus Ku autoantigen protein p70;
Thyroid-lupus autoantigen;
X-ray repair complementing defective repair in Chinese hamster cells 6
Peak binding time (min) 47.9
Cluster III
Cluster membership (corr) 0.998
Peak broadness (1 / std of log2 intensities) 0.91
Cluster expected from GO III
Subcellular localization (Human Protein Atlas) Nucleoplasm
Subcellular localization (Human Cell Map) NMF result: chromatin, SAFE result: chromatin, nucleoplasm
RMSE (expected - observed) 0.15
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of XRCC6 in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
P09874 PARP1 45.3 II Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 5 8
Q12906 ILF3 48.8 III Mitochondria;Nucleoli;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 4 3
P11387 TOP1 48.2 III Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 3 2
P19338 NCL 27.1 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 3 2
Q08211 DHX9 50.2 III Nucleus NMF result: nuclear body, SAFE result: paraspeckles 3 2
P17096 HMGA1 45.8 III Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 3 1
Q13148 TARDBP 49.3 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
Q86VM9 ZC3H18 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 2 2
Q13573 SNW1 51.8 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 2 2
O00267 SUPT5H 0.0 I Nucleoplasm NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 2 2
Q08945 SSRP1 0.0 I Cytosol;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 2
Q12873 CHD3 52.4 IV Microtubule organizing center;Nucleoli;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 2 2
P78347 GTF2I 49.8 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 2
P27694 RPA1 45.5 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 2
P26368 U2AF2 37.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: - 2 2
Q92841 DDX17 39.2 II Nuclear speckles NMF result: nuclear body, SAFE result: paraspeckles 2 1
Q02880 TOP2B 50.4 III Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 2 1
Q15233 NONO 42.9 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 1
Q86V81 ALYREF 71.2 V NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 1
P43243 MATR3 47.9 III NMF result: nuclear body, SAFE result: paraspeckles 2 1
Q16629 SRSF7 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 2 1
P17844 DDX5 40.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 1
P84103 SRSF3 43.0 II Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 2 1
O75643 SNRNP200 42.7 II Nucleoplasm NMF result: nuclear body, SAFE result: spliceosomal complex I 2 1
P11388 TOP2A 49.6 III Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 1
P46087 NOP2 57.6 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 2 1
Q5TC82 RC3H1 62.0 IV Cytosol;Plasma membrane NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 2
Q9Y5B9 SUPT16H 12.0 I Nucleoli fibrillar center;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 2
Q15637 SF1 40.9 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9UPT8 ZC3H4 33.9 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q9P2N5 RBM27 49.2 III Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q5QJE6 DNTTIP2 53.9 IV Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q06265 EXOSC9 54.5 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q92945 KHSRP 37.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q76FK4 NOL8 27.8 II Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q9P1Y6 PHRF1 36.4 II NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P21127 CDK11B 48.8 III Nuclear speckles NMF result: chromatin, SAFE result: - 1 1
Q92804 TAF15 35.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9GZT3 SLIRP 71.4 V Mitochondria NMF result: no prediction, SAFE result: no prediction 1 1
Q9H0A0 NAT10 55.7 IV Midbody;Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q96SI9 STRBP 47.4 III NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q92620 DHX38 54.2 IV Nucleus NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q8IWZ8 SUGP1 32.9 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P60842 EIF4A1 96.8 VI Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
Q4G0J3 LARP7 54.3 IV Cytosol;Nucleoplasm NMF result: nucleolus, SAFE result: paraspeckles 1 1
P82979 SARNP 70.0 V Nuclear speckles NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q15459 SF3A1 43.6 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
O75400 PRPF40A 39.8 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q00610 CLTC 33.4 II Cytosol;Mitotic spindle;Vesicles NMF result: actin cytoskeleton, cytosol, SAFE result: no prediction 1 1
Q8WXF1 PSPC1 44.9 II Nucleoli fibrillar center;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9NZM5 NOP53 89.6 V Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q9UBU9 NXF1 50.3 III Nucleoplasm NMF result: miscellaneous, SAFE result: nuclear pore 1 1
O43809 NUDT21 41.6 II Nuclear bodies NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9UNQ2 DIMT1 51.1 III Cytosol;Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q92541 RTF1 40.9 II Cytosol;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q9UIF9 BAZ2A 49.2 III Nuclear speckles NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
P61978 HNRNPK 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P46013 MKI67 62.1 V Nuclear bodies;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
P27695 APEX1 53.4 III Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q99590 SCAF11 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P27816 MAP4 62.7 V Cytosol;Microtubules;Plasma membrane NMF result: microtubule cytoskeleton, SAFE result: microtubule cytoskeleton 1 1
Q9H8H0 NOL11 24.9 II Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q8WUQ7 CACTIN 47.3 III Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q8WUA2 PPIL4 48.0 III Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q9BYG3 NIFK 58.9 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P06733 ENO1 36.6 III Cytosol;Plasma membrane NMF result: miscellaneous, SAFE result: - 1 1
Q9NR30 DDX21 0.0 I Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
O15381 NVL 49.2 III Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9H6S0 YTHDC2 171.0 VII Cytoplasmic bodies;Nuclear bodies;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q9UGN5 PARP2 49.7 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q12986 NFX1 77.5 V Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q8IX01 SUGP2 44.8 II Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
O00571 DDX3X 146.2 VII Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q5T8P6 RBM26 53.9 III Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q7Z2T5 TRMT1L 57.1 III Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q01780 EXOSC10 58.1 IV Cytosol;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9UGU0 TCF20 39.4 II Nuclear bodies;Nucleoplasm NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q9UKV3 ACIN1 60.5 IV Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q96ME7 ZNF512 45.2 III Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q9H501 ESF1 45.4 III Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q14241 ELOA 41.3 II Nuclear speckles NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9BQG0 MYBBP1A 54.4 IV Nucleoli;Vesicles NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q01844 EWSR1 36.3 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
O43395 PRPF3 48.3 III Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q13435 SF3B2 37.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P11021 HSPA5 48.9 III Cytosol NMF result: ER lumen, SAFE result: ER lumen 1 1
P51532 SMARCA4 51.3 III Nucleoplasm NMF result: nucleoplasm, SAFE result: Arp2/3 protein complex 1 1
Q7L014 DDX46 38.1 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O14776 TCERG1 40.9 II Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O75152 ZC3H11A 63.2 IV Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P23246 SFPQ 45.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O43290 SART1 39.6 II Golgi apparatus;Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9UQ35 SRRM2 42.5 III Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q14103 HNRNPD 43.1 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O95218 ZRANB2 54.2 III Nucleus NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q16630 CPSF6 33.9 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q92576 PHF3 0.0 I Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O75534 CSDE1 122.4 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P09651 HNRNPA1 43.1 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
O60264 SMARCA5 34.8 II Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q9GZR2 REXO4 52.4 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9BTC0 DIDO1 29.8 II Cytosol;Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9NYF8 BCLAF1 37.5 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q6P6C2 ALKBH5 62.7 IV Cytosol;Golgi apparatus;Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q15029 EFTUD2 45.5 III Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
Q96T58 SPEN 33.1 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q14980 NUMA1 47.8 III Nucleoplasm NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q9HCE1 MOV10 221.0 VII Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
O75533 SF3B1 40.9 II Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
Q14839 CHD4 61.8 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P29401 TKT 46.5 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q13838 DDX39B 67.1 V Nuclear speckles NMF result: nuclear body, SAFE result: no prediction 1 1
Q96KR1 ZFR 46.6 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P49750 YLPM1 44.9 III Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q7Z6E9 RBBP6 43.3 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9NXF1 TEX10 94.1 V NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q14151 SAFB2 45.8 III Nuclear bodies;Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
O75683 SURF6 56.6 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q14562 DHX8 46.2 III Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
P05455 SSB 45.1 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P39748 FEN1 52.2 III Nucleoli;Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q14498 RBM39 30.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 1 1
Q9BQ39 DDX50 23.3 II Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q7L2J0 MEPCE 53.8 III Cell Junctions;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P35637 FUS 37.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P55081 MFAP1 43.9 II NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q12905 ILF2 48.0 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q96AE4 FUBP1 36.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9Y2W1 THRAP3 37.2 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P53999 SUB1 43.3 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q13123 IK 51.9 IV Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q96QC0 PPP1R10 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q9UKM9 RALY 48.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q86XP3 DDX42 32.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9UIG0 BAZ1B 44.3 II Nuclear bodies NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q14966 ZNF638 47.8 III Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q96EV2 RBM33 56.1 IV Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13823 GNL2 111.9 VI Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q15365 PCBP1 48.6 III Cytoplasmic bodies;Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
Q9Y6V7 DDX49 46.5 III Mitochondria;Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q5VT52 RPRD2 8.3 I Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
Q9BY77 POLDIP3 74.6 V Cytoplasmic bodies;Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P55265 ADAR 48.0 III Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
O60231 DHX16 48.9 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P12270 TPR 53.6 IV Nuclear membrane NMF result: no prediction, SAFE result: no prediction 1 1
Q13206 DDX10 41.7 II Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q15061 WDR43 34.7 II NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P98175 RBM10 33.0 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1