NONO

UniProt Accession Q15233 UniProt 🔗
Synonyms NRB54
UniProt protein names Non-POU domain-containing octamer-binding protein;
54 kDa nuclear RNA- and DNA-binding protein;
55 kDa nuclear protein;
DNA-binding p52/p100 complex, 52 kDa subunit
Peak binding time (min) 42.9
Cluster II
Cluster membership (corr) 0.999
Peak broadness (1 / std of log2 intensities) 0.89
Cluster expected from GO II
Subcellular localization (Human Protein Atlas) Nucleoplasm
Subcellular localization (Human Cell Map) NMF result: nuclear body, SAFE result: paraspeckles
RMSE (expected - observed) 0.19
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of NONO in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
P23246 SFPQ 45.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 6 11
P26368 U2AF2 37.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: - 3 3
P51532 SMARCA4 51.3 III Nucleoplasm NMF result: nucleoplasm, SAFE result: Arp2/3 protein complex 3 2
Q8WXF1 PSPC1 44.9 II Nucleoli fibrillar center;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 4
P35637 FUS 37.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 3
P49750 YLPM1 44.9 III Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
Q15717 ELAVL1 46.3 III Cytosol;Nucleoli;Nucleus NMF result: miscellaneous, SAFE result: paraspeckles 2 2
P09651 HNRNPA1 43.1 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 2 2
P12956 XRCC6 47.9 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 1
Q5TC82 RC3H1 62.0 IV Cytosol;Plasma membrane NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 2
Q01844 EWSR1 36.3 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
O14776 TCERG1 40.9 II Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P43243 MATR3 47.9 III NMF result: nuclear body, SAFE result: paraspeckles 1 1
O75152 ZC3H11A 63.2 IV Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P27694 RPA1 45.5 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
O14979 HNRNPDL 43.3 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q92879 CELF1 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P18583 SON 43.3 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P33240 CSTF2 23.7 II Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 1 1
Q9UQ35 SRRM2 42.5 III Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P52272 HNRNPM 46.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q99459 CDC5L 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q13573 SNW1 51.8 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q7L2J0 MEPCE 53.8 III Cell Junctions;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q92804 TAF15 35.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O95793 STAU1 111.0 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q16630 CPSF6 33.9 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P11387 TOP1 48.2 III Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
P09012 SNRPA 44.9 III Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P51116 FXR2 171.1 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P26599 PTBP1 46.5 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P51991 HNRNPA3 43.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8IX01 SUGP2 44.8 II Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q4G0J3 LARP7 54.3 IV Cytosol;Nucleoplasm NMF result: nucleolus, SAFE result: paraspeckles 1 1
Q15029 EFTUD2 45.5 III Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
O75400 PRPF40A 39.8 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q15365 PCBP1 48.6 III Cytoplasmic bodies;Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
Q86VM9 ZC3H18 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P08621 SNRNP70 32.2 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q00839 HNRNPU 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q14839 CHD4 61.8 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q6P158 DHX57 78.3 VI Cytosol;Intermediate filaments;Microtubules;Nucleoli NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q8IYB3 SRRM1 39.4 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q12873 CHD3 52.4 IV Microtubule organizing center;Nucleoli;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1