SF3B2
| UniProt Accession | Q13435 UniProt 🔗 |
|---|---|
| Synonyms | SAP145 |
| UniProt protein names | Splicing factor 3B subunit 2;Pre-mRNA-splicing factor SF3b 145 kDa subunit;Spliceosome-associated protein 145 |
| Peak binding time (min) | 37.6 |
| Cluster | II |
| Cluster membership (corr) | 0.998 |
| Peak broadness (1 / std of log2 intensities) | 1.04 |
| Cluster expected from GO | III |
| Subcellular localization (Human Protein Atlas) | Nuclear speckles |
| Subcellular localization (Human Cell Map) | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus |
| RMSE (expected - observed) | 0.23 |
| Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of SF3B2 in mRNP (BioGRID)
| Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
|---|---|---|---|---|---|---|---|
| Q15427 | SF3B4 | 38.3 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 4 | 6 |
| O75533 | SF3B1 | 40.9 | II | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 3 | 5 |
| Q9Y580 | RBM7 | 36.4 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 3 | 4 |
| P26368 | U2AF2 | 37.3 | II | Nuclear speckles;Nucleoplasm | NMF result: nuclear body, SAFE result: - | 2 | 3 |
| Q15393 | SF3B3 | 45.7 | II | Nucleoli;Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 2 | 3 |
| Q15428 | SF3A2 | 31.3 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 2 | 3 |
| O14776 | TCERG1 | 40.9 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 2 |
| Q99459 | CDC5L | 49.2 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 2 |
| O75400 | PRPF40A | 39.8 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 2 | 2 |
| O60231 | DHX16 | 48.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 1 |
| O43395 | PRPF3 | 48.3 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 2 | 1 |
| O75643 | SNRNP200 | 42.7 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: spliceosomal complex I | 1 | 2 |
| Q9Y3B4 | SF3B6 | 36.0 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| Q5TC82 | RC3H1 | 62.0 | IV | Cytosol;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 2 |
| Q05519 | SRSF11 | 52.0 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q01844 | EWSR1 | 36.3 | II | Nucleoli;Nucleus | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P67809 | YBX1 | 148.5 | VII | Cytosol;Vesicles | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q8NDF8 | TENT4B | 47.1 | III | NMF result: no prediction, SAFE result: no prediction | 1 | 1 | |
| P43243 | MATR3 | 47.9 | III | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 | |
| P27694 | RPA1 | 45.5 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9UQ35 | SRRM2 | 42.5 | III | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q13242 | SRSF9 | 44.3 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P12956 | XRCC6 | 47.9 | III | Nucleoplasm | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| P62314 | SNRPD1 | 54.6 | IV | NMF result: nuclear body, SAFE result: spliceosomal complex I | 1 | 1 | |
| Q7RTV0 | PHF5A | 37.6 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q8IYB3 | SRRM1 | 39.4 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q13573 | SNW1 | 51.8 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P38919 | EIF4A3 | 67.1 | V | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P61326 | MAGOH | 70.2 | V | Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q7L2J0 | MEPCE | 53.8 | III | Cell Junctions;Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| P35637 | FUS | 37.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q8TAD8 | SNIP1 | 40.9 | II | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q15366 | PCBP2 | 48.9 | III | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| O95793 | STAU1 | 111.0 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q92804 | TAF15 | 35.0 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q69YN4 | VIRMA | 0.0 | I | Nuclear bodies;Nucleoplasm | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9BTD8 | RBM42 | 40.1 | II | Cytosol;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9Y2W1 | THRAP3 | 37.2 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P07910 | HNRNPC | 47.9 | III | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q8TBF4 | ZCRB1 | 36.7 | II | NMF result: no prediction, SAFE result: no prediction | 1 | 1 | |
| O96028 | NSD2 | 41.7 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| O75940 | SMNDC1 | 36.3 | II | Nuclear bodies;Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q4G0J3 | LARP7 | 54.3 | IV | Cytosol;Nucleoplasm | NMF result: nucleolus, SAFE result: paraspeckles | 1 | 1 |
| Q06787 | FMR1 | 176.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q6Y7W6 | GIGYF2 | 61.8 | IV | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q15029 | EFTUD2 | 45.5 | III | Cytosol;Nucleoplasm | NMF result: miscellaneous, SAFE result: spliceosomal complex I | 1 | 1 |
| P38159 | RBMX | 44.4 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9Y5S9 | RBM8A | 77.3 | V | Nuclear speckles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q86VM9 | ZC3H18 | 39.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q03701 | CEBPZ | 52.3 | III | Nucleus;Vesicles | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P08621 | SNRNP70 | 32.2 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q96GM8 | TOE1 | 50.0 | III | Nuclear bodies;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q14839 | CHD4 | 61.8 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9UGY1 | NOL12 | 73.1 | V | Nucleoli;Nucleus;Vesicles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q8N5P1 | ZC3H8 | 51.6 | III | Nuclear bodies;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| P98175 | RBM10 | 33.0 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9BQ67 | GRWD1 | 42.3 | II | Nucleoli;Nucleus | NMF result: plasma membrane, SAFE result: - | 1 | 1 |
| Q12873 | CHD3 | 52.4 | IV | Microtubule organizing center;Nucleoli;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |