PKM

UniProt Accession P14618 UniProt 🔗
Synonyms OIP3, PK2, PK3, PKM2
UniProt protein names Pyruvate kinase PKM;
Cytosolic thyroid hormone-binding protein;
Opa-interacting protein 3;
Pyruvate kinase 2/3;
Pyruvate kinase muscle isozyme;
Threonine-protein kinase PKM2;
Thyroid hormone-binding protein 1;
Tumor M2-PK;
Tyrosine-protein kinase PKM2;
p58
Peak binding time (min) 44.0
Cluster III
Cluster membership (corr) 0.992
Peak broadness (1 / std of log2 intensities) 1.16
Cluster expected from GO II
Subcellular localization (Human Protein Atlas) Cytosol
Subcellular localization (Human Cell Map) NMF result: miscellaneous, SAFE result: no prediction
RMSE (expected - observed) 0.13
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of PKM in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
Q15365 PCBP1 48.6 III Cytoplasmic bodies;Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 2
P04406 GAPDH 42.0 III Cytosol;Plasma membrane NMF result: mitochondrial outer membrane, peroxisome, SAFE result: - 1 2
Q01844 EWSR1 36.3 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
P33992 MCM5 42.8 III Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P07437 TUBB 34.3 II Microtubules NMF result: no prediction, SAFE result: no prediction 1 1
Q96EP5 DAZAP1 37.4 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P00338 LDHA 44.4 III Cytosol;Vesicles NMF result: miscellaneous, SAFE result: no prediction 1 1
P61978 HNRNPK 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P07195 LDHB 56.6 IV Cytosol NMF result: miscellaneous, SAFE result: no prediction 1 1
P06748 NPM1 56.1 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q14103 HNRNPD 43.1 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P68104 EEF1A1 42.8 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
P38919 EIF4A3 67.1 V Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P08238 HSP90AB1 46.0 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
P26368 U2AF2 37.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: - 1 1
Q7L2J0 MEPCE 53.8 III Cell Junctions;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P35637 FUS 37.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O95793 STAU1 111.0 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q96AE4 FUBP1 36.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P20073 ANXA7 37.9 II Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P37108 SRP14 45.6 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q12986 NFX1 77.5 V Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P61026 RAB10 40.3 II NMF result: plasma membrane, SAFE result: no prediction 1 1
P09651 HNRNPA1 43.1 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q4G0J3 LARP7 54.3 IV Cytosol;Nucleoplasm NMF result: nucleolus, SAFE result: paraspeckles 1 1
Q15029 EFTUD2 45.5 III Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
P07900 HSP90AA1 48.1 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
Q86VM9 ZC3H18 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P29401 TKT 46.5 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1