RPA1

UniProt Accession P27694 UniProt 🔗
Synonyms REPA1, RPA70
UniProt protein names Replication protein A 70 kDa DNA-binding subunit;
Replication factor A protein 1;
Single-stranded DNA-binding protein;
Replication protein A 70 kDa DNA-binding subunit, N-terminally processed
Peak binding time (min) 45.5
Cluster III
Cluster membership (corr) 0.992
Peak broadness (1 / std of log2 intensities) 2.09
Cluster expected from GO II
Subcellular localization (Human Protein Atlas) Nucleoplasm
Subcellular localization (Human Cell Map) NMF result: chromatin, SAFE result: chromatin, nucleoplasm
RMSE (expected - observed) 0.14
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of RPA1 in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
Q9BUJ2 HNRNPUL1 42.4 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 3 2
Q99459 CDC5L 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 2 2
P12956 XRCC6 47.9 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 2
Q14527 HLTF 49.9 III Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 3
P09874 PARP1 45.3 II Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 2
O95104 SCAF4 0.0 I Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P43243 MATR3 47.9 III NMF result: nuclear body, SAFE result: paraspeckles 1 1
P42285 MTREX 73.4 V Nucleus NMF result: chromatin, SAFE result: - 1 1
Q9P2N5 RBM27 49.2 III Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O43823 AKAP8 42.3 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O14979 HNRNPDL 43.3 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P49756 RBM25 34.8 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P04406 GAPDH 42.0 III Cytosol;Plasma membrane NMF result: mitochondrial outer membrane, peroxisome, SAFE result: - 1 1
P07814 EPRS 29.5 II Cytosol NMF result: actin cytoskeleton, cytosol, SAFE result: cell junction, plasma membrane 1 1
Q12906 ILF3 48.8 III Mitochondria;Nucleoli;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8IY67 RAVER1 48.3 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13573 SNW1 51.8 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O43251 RBFOX2 45.8 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q92804 TAF15 35.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P98179 RBM3 43.6 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q8TEQ6 GEMIN5 42.4 III Cytosol;Nuclear bodies NMF result: no prediction, SAFE result: no prediction 1 1
Q96SI9 STRBP 47.4 III NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q08211 DHX9 50.2 III Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q15459 SF3A1 43.6 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
O75400 PRPF40A 39.8 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q00610 CLTC 33.4 II Cytosol;Mitotic spindle;Vesicles NMF result: actin cytoskeleton, cytosol, SAFE result: no prediction 1 1
P22626 HNRNPA2B1 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8N684 CPSF7 36.9 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13148 TARDBP 49.3 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O43809 NUDT21 41.6 II Nuclear bodies NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9H2U1 DHX36 50.1 III Cytosol;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q96EP5 DAZAP1 37.4 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q92499 DDX1 74.7 V Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P00338 LDHA 44.4 III Cytosol;Vesicles NMF result: miscellaneous, SAFE result: no prediction 1 1
P11388 TOP2A 49.6 III Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P61978 HNRNPK 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q15717 ELAVL1 46.3 III Cytosol;Nucleoli;Nucleus NMF result: miscellaneous, SAFE result: paraspeckles 1 1
P27695 APEX1 53.4 III Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
P27816 MAP4 62.7 V Cytosol;Microtubules;Plasma membrane NMF result: microtubule cytoskeleton, SAFE result: microtubule cytoskeleton 1 1
P31943 HNRNPH1 40.8 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P20073 ANXA7 37.9 II Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q9C0J8 WDR33 24.7 II Nucleoli fibrillar center;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q96I24 FUBP3 51.8 III Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles 1 1
O00571 DDX3X 146.2 VII Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q5T8P6 RBM26 53.9 III Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P62820 RAB1A 45.1 III Cytosol;Endoplasmic reticulum NMF result: mitochondrial outer membrane, peroxisome, SAFE result: no prediction 1 1
Q9BWF3 RBM4 40.3 II Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P11142 HSPA8 45.1 III Nucleoplasm;Vesicles NMF result: miscellaneous, SAFE result: no prediction 1 1
Q92841 DDX17 39.2 II Nuclear speckles NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q01780 EXOSC10 58.1 IV Cytosol;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q07666 KHDRBS1 43.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9H0J9 PARP12 46.6 IV Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
O75643 SNRNP200 42.7 II Nucleoplasm NMF result: nuclear body, SAFE result: spliceosomal complex I 1 1
Q00839 HNRNPU 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q02880 TOP2B 50.4 III Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q96QR8 PURB 143.9 VII Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q01844 EWSR1 36.3 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13435 SF3B2 37.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P11021 HSPA5 48.9 III Cytosol NMF result: ER lumen, SAFE result: ER lumen 1 1
Q96T37 RBM15 30.8 II Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 1 1
Q7L014 DDX46 38.1 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O14776 TCERG1 40.9 II Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P07437 TUBB 34.3 II Microtubules NMF result: no prediction, SAFE result: no prediction 1 1
P23246 SFPQ 45.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P78347 GTF2I 49.8 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q92879 CELF1 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O95985 TOP3B 72.2 V Vesicles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9BYJ9 YTHDF1 222.1 VII NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q8IWX8 CHERP 23.2 II NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9NRR4 DROSHA 45.3 III NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P24928 POLR2A 0.0 I Nucleoplasm NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm 1 1
P06748 NPM1 56.1 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q15393 SF3B3 45.7 II Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q14103 HNRNPD 43.1 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9H0D6 XRN2 41.9 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q14444 CAPRIN1 229.7 VII NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q7Z739 YTHDF3 111.3 VI Cytosol;Nuclear membrane;Nuclear speckles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P26599 PTBP1 46.5 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13310 PABPC4 147.7 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9H6T0 ESRP2 55.2 IV Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P51991 HNRNPA3 43.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P09651 HNRNPA1 43.1 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
O60264 SMARCA5 34.8 II Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
P05198 EIF2S1 98.9 VI Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: - 1 1
Q9BTC0 DIDO1 29.8 II Cytosol;Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O14828 SCAMP3 45.6 III Vesicles NMF result: endosome, lysosome, SAFE result: endosome, lysosome 1 1
Q15029 EFTUD2 45.5 III Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
Q14980 NUMA1 47.8 III Nucleoplasm NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q8N5C6 SRBD1 38.5 III Cytosol;Mitochondria NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q9HCE1 MOV10 221.0 VII Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
P14866 HNRNPL 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P48634 PRRC2A 106.7 VI Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
O75533 SF3B1 40.9 II Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
P11940 PABPC1 124.3 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q14839 CHD4 61.8 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q96KR1 ZFR 46.6 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q6NZY4 ZCCHC8 40.2 II Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: - 1 1
O94906 PRPF6 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: spliceosomal complex I 1 1
P19338 NCL 27.1 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P17844 DDX5 40.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9NXF1 TEX10 94.1 V NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
P33992 MCM5 42.8 III Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q9BYW2 SETD2 28.3 II Cytosol;Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9BUQ8 DDX23 47.0 III Nucleoli;Nucleus NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
Q9Y5A9 YTHDF2 111.0 VI Cytoplasmic bodies;Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q15233 NONO 42.9 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q14498 RBM39 30.3 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: no prediction 1 1
P52272 HNRNPM 46.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q96PK6 RBM14 42.9 II Nuclear speckles NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9BRJ6 C7orf50 51.1 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
P68104 EEF1A1 42.8 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
O15042 U2SURP 33.1 II Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P35637 FUS 37.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q12905 ILF2 48.0 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q96AE4 FUBP1 36.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q08J23 NSUN2 52.7 III Nucleus NMF result: miscellaneous, SAFE result: - 1 1
P52597 HNRNPF 42.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q01085 TIAL1 46.1 II Nucleus;Vesicles NMF result: no prediction, SAFE result: no prediction 1 1
Q96QC0 PPP1R10 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P61026 RAB10 40.3 II NMF result: plasma membrane, SAFE result: no prediction 1 1
Q9UKM9 RALY 48.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13428 TCOF1 0.0 I Nucleoli fibrillar center NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q14966 ZNF638 47.8 III Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O43143 DHX15 35.8 II Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
Q13151 HNRNPA0 43.7 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q5VT52 RPRD2 8.3 I Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
O60506 SYNCRIP 71.4 V Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles 1 1
Q99729 HNRNPAB 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P55265 ADAR 48.0 III Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q96DH6 MSI2 93.6 V Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
Q9NV06 DCAF13 49.2 III Cell Junctions;Centrosome;Cytosol;Nucleoli;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: splicing speckles, nucleolus 1 1
P98175 RBM10 33.0 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
O43390 HNRNPR 48.0 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1