APEX1

UniProt Accession P27695 UniProt 🔗
Synonyms APE, APE1, APEX, APX, HAP1, REF1
UniProt protein names DNA-(apurinic or apyrimidinic site) endonuclease;
APEX nuclease;
Apurinic-apyrimidinic endonuclease 1;
REF-1;
Redox factor-1;
DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial
Peak binding time (min) 53.4
Cluster III
Cluster membership (corr) 0.982
Peak broadness (1 / std of log2 intensities) 1.70
Cluster expected from GO III
Subcellular localization (Human Protein Atlas) Nucleus
Subcellular localization (Human Cell Map) NMF result: no prediction, SAFE result: no prediction
RMSE (expected - observed) 0.12
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of APEX1 in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
P11940 PABPC1 124.3 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 4 2
P23246 SFPQ 45.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 3 2
P17987 TCP1 45.1 III NMF result: miscellaneous, SAFE result: chaperonin-containing T-complex, prefoldin complex 2 2
P06748 NPM1 56.1 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 2 2
P14866 HNRNPL 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
P67809 YBX1 148.5 VII Cytosol;Vesicles NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 2 2
Q00839 HNRNPU 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 1
P17096 HMGA1 45.8 III Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 1
P39748 FEN1 52.2 III Nucleoli;Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 1
P19338 NCL 27.1 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 2 1
Q9NRR4 DROSHA 45.3 III NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 2 1
P43243 MATR3 47.9 III NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q96SB4 SRPK1 52.0 IV Cytosol;Nucleus;Plasma membrane NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q06265 EXOSC9 54.5 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q13283 G3BP1 220.8 VII Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P62314 SNRPD1 54.6 IV NMF result: nuclear body, SAFE result: spliceosomal complex I 1 1
Q15287 RNPS1 58.0 IV Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P98179 RBM3 43.6 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q6Y7W6 GIGYF2 61.8 IV Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q03701 CEBPZ 52.3 III Nucleus;Vesicles NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q13148 TARDBP 49.3 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9UBU9 NXF1 50.3 III Nucleoplasm NMF result: miscellaneous, SAFE result: nuclear pore 1 1
Q9H2U1 DHX36 50.1 III Cytosol;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
P27694 RPA1 45.5 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P49761 CLK3 52.9 III Intermediate filaments;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q96QD9 FYTTD1 75.0 V Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
P61978 HNRNPK 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8ND56 LSM14A 138.4 VII Cytoplasmic bodies;Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P46087 NOP2 57.6 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P31943 HNRNPH1 40.8 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9BYG3 NIFK 58.9 IV Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q8WVV9 HNRNPLL 43.8 II Cytosol;Mitochondria;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
O96028 NSD2 41.7 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q04637 EIF4G1 105.0 VI Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
Q14004 CDK13 37.1 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O00571 DDX3X 146.2 VII Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
Q71RC2 LARP4 130.6 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q96PZ0 PUS7 44.5 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q14011 CIRBP 41.6 II Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
O00267 SUPT5H 0.0 I Nucleoplasm NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q96BK5 PINX1 0.0 I NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q8IYB3 SRRM1 39.4 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q01844 EWSR1 36.3 II Nucleoli;Nucleus NMF result: nuclear body, SAFE result: paraspeckles 1 1
P51532 SMARCA4 51.3 III Nucleoplasm NMF result: nucleoplasm, SAFE result: Arp2/3 protein complex 1 1
P35659 DEK 45.5 II Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q13243 SRSF5 41.7 II Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q16630 CPSF6 33.9 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P07910 HNRNPC 47.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P09651 HNRNPA1 43.1 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q9GZR2 REXO4 52.4 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9BTC0 DIDO1 29.8 II Cytosol;Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q15029 EFTUD2 45.5 III Cytosol;Nucleoplasm NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
Q15424 SAFB 45.0 II Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P48634 PRRC2A 106.7 VI Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P62995 TRA2B 42.0 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q9ULR0 ISY1 50.1 III Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
Q14839 CHD4 61.8 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q96PU8 QKI 47.1 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P17844 DDX5 40.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9BUQ8 DDX23 47.0 III Nucleoli;Nucleus NMF result: miscellaneous, SAFE result: spliceosomal complex I 1 1
Q6PJT7 ZC3H14 65.7 IV Nuclear speckles NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
Q9NXH9 TRMT1 49.2 III Cytosol;Nucleus;Plasma membrane NMF result: mitochondrial matrix, SAFE result: mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix 1 1
Q9BUJ2 HNRNPUL1 42.4 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13242 SRSF9 44.3 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P12956 XRCC6 47.9 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q9BRD0 BUD13 34.9 II Nucleus NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9H7E2 TDRD3 89.3 VI Cytosol;Golgi apparatus;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
P26038 MSN 40.3 II Plasma membrane NMF result: actin cytoskeleton, cytosol, SAFE result: cell junction, plasma membrane 1 1
Q9Y2W1 THRAP3 37.2 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P52597 HNRNPF 42.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O43709 BUD23 53.4 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q01085 TIAL1 46.1 II Nucleus;Vesicles NMF result: no prediction, SAFE result: no prediction 1 1
Q14966 ZNF638 47.8 III Nucleoplasm;Vesicles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
O15260 SURF4 38.5 II NMF result: mitochondrial outer membrane, peroxisome, SAFE result: no prediction 1 1
Q9BY77 POLDIP3 74.6 V Cytoplasmic bodies;Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P55265 ADAR 48.0 III Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
O60231 DHX16 48.9 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q7Z2W4 ZC3HAV1 211.8 VII Cytosol;Golgi apparatus NMF result: nuclear outer membrane-ER membrane network, SAFE result: nuclear outer membrane-ER membrane network 1 1