NSD2

UniProt Accession O96028 UniProt 🔗
Synonyms KIAA1090, MMSET, TRX5, WHSC1
UniProt protein names Histone-lysine N-methyltransferase NSD2;
Multiple myeloma SET domain-containing protein;
Nuclear SET domain-containing protein 2;
Protein trithorax-5;
Wolf-Hirschhorn syndrome candidate 1 protein
Peak binding time (min) 41.7
Cluster III
Cluster membership (corr) 0.988
Peak broadness (1 / std of log2 intensities) 2.44
Cluster expected from GO II
Subcellular localization (Human Protein Atlas) Nucleus
Subcellular localization (Human Cell Map) NMF result: chromatin, SAFE result: chromatin, nucleoplasm
RMSE (expected - observed) 0.18
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of NSD2 in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
P09874 PARP1 45.3 II Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 2 1
Q8TEQ6 GEMIN5 42.4 III Cytosol;Nuclear bodies NMF result: no prediction, SAFE result: no prediction 2 1
Q9UKV8 AGO2 103.6 VI Cell Junctions;Nucleoplasm NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched 2 1
P19338 NCL 27.1 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q13435 SF3B2 37.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q15149 PLEC 59.3 V Cytosol;Focal adhesion sites;Intermediate filaments NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched 1 1
Q7L014 DDX46 38.1 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P42285 MTREX 73.4 V Nucleus NMF result: chromatin, SAFE result: - 1 1
P78347 GTF2I 49.8 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P39748 FEN1 52.2 III Nucleoli;Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q9UIF9 BAZ2A 49.2 III Nuclear speckles NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
P61978 HNRNPK 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P11388 TOP2A 49.6 III Nucleoli;Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P46013 MKI67 62.1 V Nuclear bodies;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
P27695 APEX1 53.4 III Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
P06748 NPM1 56.1 IV Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P62633 CNBP 105.4 VI Cytosol;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
Q8IY81 FTSJ3 69.4 V Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
O95793 STAU1 111.0 VI Cytosol NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
P11387 TOP1 48.2 III Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
P06733 ENO1 36.6 III Cytosol;Plasma membrane NMF result: miscellaneous, SAFE result: - 1 1
P09429 HMGB1 49.8 III Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9Y2W1 THRAP3 37.2 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P53999 SUB1 43.3 II Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9BZE4 GTPBP4 76.2 V Nuclear membrane;Nucleoli NMF result: nucleolus, SAFE result: no prediction 1 1
Q5SSJ5 HP1BP3 50.5 III Nuclear speckles NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q9BQ04 RBM4B 37.1 II Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q86V81 ALYREF 71.2 V NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
O60264 SMARCA5 34.8 II Nucleoli fibrillar center;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q9UIG0 BAZ1B 44.3 II Nuclear bodies NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q13428 TCOF1 0.0 I Nucleoli fibrillar center NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q7Z2W4 ZC3HAV1 211.8 VII Cytosol;Golgi apparatus NMF result: nuclear outer membrane-ER membrane network, SAFE result: nuclear outer membrane-ER membrane network 1 1
Q1ED39 KNOP1 38.4 II Cytosol;Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q14980 NUMA1 47.8 III Nucleoplasm NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1
Q15365 PCBP1 48.6 III Cytoplasmic bodies;Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
P14866 HNRNPL 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9NZM5 NOP53 89.6 V Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
O43159 RRP8 43.2 II Cytosol;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q00839 HNRNPU 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q14839 CHD4 61.8 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
P12270 TPR 53.6 IV Nuclear membrane NMF result: no prediction, SAFE result: no prediction 1 1
P98175 RBM10 33.0 II Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q9BQG0 MYBBP1A 54.4 IV Nucleoli;Vesicles NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1