BRIX1
| UniProt Accession | Q8TDN6 UniProt 🔗 |
|---|---|
| Synonyms | BRIX, BXDC2 |
| UniProt protein names | Ribosome biogenesis protein BRX1 homolog;Brix domain-containing protein 2 |
| Peak binding time (min) | 58.0 |
| Cluster | IV |
| Cluster membership (corr) | 0.997 |
| Peak broadness (1 / std of log2 intensities) | 1.40 |
| Cluster expected from GO | IV |
| Subcellular localization (Human Protein Atlas) | Nucleoli |
| Subcellular localization (Human Cell Map) | NMF result: miscellaneous, SAFE result: no prediction |
| RMSE (expected - observed) | 0.08 |
| Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of BRIX1 in mRNP (BioGRID)
| Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
|---|---|---|---|---|---|---|---|
| Q9BYG3 | NIFK | 58.9 | IV | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 2 | 3 |
| O95793 | STAU1 | 111.0 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 2 | 3 |
| Q00839 | HNRNPU | 42.8 | II | Nucleoplasm | NMF result: nuclear body, SAFE result: paraspeckles | 2 | 2 |
| Q15397 | PUM3 | 58.6 | IV | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 2 | 2 |
| P78563 | ADARB1 | 48.2 | III | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 2 | 1 |
| P62633 | CNBP | 105.4 | VI | Cytosol;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| Q12905 | ILF2 | 48.0 | III | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 2 |
| P06748 | NPM1 | 56.1 | IV | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 2 |
| P42696 | RBM34 | 41.1 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P19338 | NCL | 27.1 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9NX58 | LYAR | 25.6 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q5TC82 | RC3H1 | 62.0 | IV | Cytosol;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| P46013 | MKI67 | 62.1 | V | Nuclear bodies;Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9NY61 | AATF | 53.8 | IV | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 | |
| P46087 | NOP2 | 57.6 | IV | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q8WTT2 | NOC3L | 66.5 | V | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q5JTH9 | RRP12 | 53.2 | III | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q8IY81 | FTSJ3 | 69.4 | V | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9NY93 | DDX56 | 51.2 | III | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 | |
| Q9BZE4 | GTPBP4 | 76.2 | V | Nuclear membrane;Nucleoli | NMF result: nucleolus, SAFE result: no prediction | 1 | 1 |
| Q13310 | PABPC4 | 147.7 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9BQ04 | RBM4B | 37.1 | II | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9GZR7 | DDX24 | 58.0 | IV | Cytosol;Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q4G0J3 | LARP7 | 54.3 | IV | Cytosol;Nucleoplasm | NMF result: nucleolus, SAFE result: paraspeckles | 1 | 1 |
| Q9BWF3 | RBM4 | 40.3 | II | Cytosol;Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q15029 | EFTUD2 | 45.5 | III | Cytosol;Nucleoplasm | NMF result: miscellaneous, SAFE result: spliceosomal complex I | 1 | 1 |
| Q8TED0 | UTP15 | 46.7 | III | Endoplasmic reticulum;Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q86VM9 | ZC3H18 | 39.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| O43159 | RRP8 | 43.2 | II | Cytosol;Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q14011 | CIRBP | 41.6 | II | Nucleoli;Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q9NZM5 | NOP53 | 89.6 | V | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9NVP1 | DDX18 | 49.1 | III | Nucleoli | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| P11940 | PABPC1 | 124.3 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P08621 | SNRNP70 | 32.2 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q14839 | CHD4 | 61.8 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q9UGY1 | NOL12 | 73.1 | V | Nucleoli;Nucleus;Vesicles | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q7Z2W4 | ZC3HAV1 | 211.8 | VII | Cytosol;Golgi apparatus | NMF result: nuclear outer membrane-ER membrane network, SAFE result: nuclear outer membrane-ER membrane network | 1 | 1 |
| Q12873 | CHD3 | 52.4 | IV | Microtubule organizing center;Nucleoli;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |