XRN2

UniProt Accession Q9H0D6 UniProt 🔗
Synonyms
UniProt protein names 5'-3' exoribonuclease 2;
DHM1-like protein
Peak binding time (min) 41.9
Cluster II
Cluster membership (corr) 0.996
Peak broadness (1 / std of log2 intensities) 1.05
Cluster expected from GO II
Subcellular localization (Human Protein Atlas) Nucleoli;Nucleus
Subcellular localization (Human Cell Map) NMF result: nuclear body, SAFE result: paraspeckles
RMSE (expected - observed) 0.12
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics

Gene Ontology based expectation (GO 2021-09-01)

Protein interactors of XRN2 in mRNP (BioGRID)

Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
Q13148 TARDBP 49.3 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 2 2
Q9HCE1 MOV10 221.0 VII Cytosol NMF result: no prediction, SAFE result: no prediction 2 2
Q9UBU9 NXF1 50.3 III Nucleoplasm NMF result: miscellaneous, SAFE result: nuclear pore 2 2
P24928 POLR2A 0.0 I Nucleoplasm NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm 2 2
O15226 NKRF 47.5 III Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 2 2
P09651 HNRNPA1 43.1 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 2 1
Q4G0J3 LARP7 54.3 IV Cytosol;Nucleoplasm NMF result: nucleolus, SAFE result: paraspeckles 1 2
Q8IWA0 WDR75 47.1 III Nucleoplasm NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P78332 RBM6 38.1 II Cytoplasmic bodies;Nuclear speckles NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9NXF1 TEX10 94.1 V NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9UPT8 ZC3H4 33.9 II Cytosol;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q9NTZ6 RBM12 40.9 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P27694 RPA1 45.5 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q9BZZ5 API5 69.0 V Nuclear speckles NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
Q14562 DHX8 46.2 III Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: spliceosomal complex II 1 1
Q96EY7 PTCD3 77.4 V Mitochondria NMF result: mitochondrial matrix, SAFE result: mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix 1 1
Q92879 CELF1 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9Y262 EIF3L 193.3 VII Nucleoli;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 1 1
O60306 AQR 46.9 III Nucleoplasm NMF result: nuclear body, SAFE result: spliceosomal complex I 1 1
Q9BUJ2 HNRNPUL1 42.4 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P61978 HNRNPK 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q13242 SRSF9 44.3 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q15717 ELAVL1 46.3 III Cytosol;Nucleoli;Nucleus NMF result: miscellaneous, SAFE result: paraspeckles 1 1
P46013 MKI67 62.1 V Nuclear bodies;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
P30876 POLR2B 0.0 I Nucleoplasm NMF result: miscellaneous, SAFE result: chromatin, nucleoplasm 1 1
Q12906 ILF3 48.8 III Mitochondria;Nucleoli;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9H8H0 NOL11 24.9 II Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q8IY67 RAVER1 48.3 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q07955 SRSF1 41.6 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q99459 CDC5L 49.2 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P68104 EEF1A1 42.8 III Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
Q13573 SNW1 51.8 III Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P49750 YLPM1 44.9 III Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q7L2J0 MEPCE 53.8 III Cell Junctions;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P35637 FUS 37.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8TAD8 SNIP1 40.9 II Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q16630 CPSF6 33.9 II Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P06733 ENO1 36.6 III Cytosol;Plasma membrane NMF result: miscellaneous, SAFE result: - 1 1
Q12905 ILF2 48.0 III Nucleoli;Nucleus NMF result: no prediction, SAFE result: no prediction 1 1
P07910 HNRNPC 47.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q96SI9 STRBP 47.4 III NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q12986 NFX1 77.5 V Cytosol;Nucleus NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule 1 1
Q9C0J8 WDR33 24.7 II Nucleoli fibrillar center;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P51991 HNRNPA3 43.2 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q5SY16 NOL9 53.1 IV Intermediate filaments;Nucleoli NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q9UKM9 RALY 48.9 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q9H2Y7 ZNF106 35.1 II Cytosol;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
P63241 EIF5A 53.2 III Cytosol;Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
O43143 DHX15 35.8 II Nuclear speckles NMF result: no prediction, SAFE result: no prediction 1 1
Q96EV2 RBM33 56.1 IV Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8NEY8 PPHLN1 35.3 II Golgi apparatus;Nucleoplasm NMF result: nuclear body, SAFE result: chromatin, nucleoplasm 1 1
P38159 RBMX 44.4 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O95758 PTBP3 55.2 IV Nucleus NMF result: nucleoplasm, SAFE result: - 1 1
Q01780 EXOSC10 58.1 IV Cytosol;Nucleoli;Nucleus NMF result: nucleolus, SAFE result: chromatin, nucleoplasm 1 1
Q8WXF1 PSPC1 44.9 II Nucleoli fibrillar center;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q8TED0 UTP15 46.7 III Endoplasmic reticulum;Nucleoli NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q03701 CEBPZ 52.3 III Nucleus;Vesicles NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q86VM9 ZC3H18 39.6 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
P14866 HNRNPL 42.6 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P08621 SNRNP70 32.2 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
P22626 HNRNPA2B1 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O60506 SYNCRIP 71.4 V Cytosol;Nucleoplasm NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles 1 1
P62995 TRA2B 42.0 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
Q99729 HNRNPAB 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q00839 HNRNPU 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q14839 CHD4 61.8 III Nucleus NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q15061 WDR43 34.7 II NMF result: nucleolus, SAFE result: splicing speckles, nucleolus 1 1
Q9BQ67 GRWD1 42.3 II Nucleoli;Nucleus NMF result: plasma membrane, SAFE result: - 1 1
Q96KR1 ZFR 46.6 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O43390 HNRNPR 48.0 III Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q12873 CHD3 52.4 IV Microtubule organizing center;Nucleoli;Nucleus NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm 1 1