DROSHA


UniProt Accession Q9NRR4 UniProt 🔗
Synonyms RN3, RNASE3L, RNASEN
UniProt protein names Ribonuclease 3;
Protein Drosha;
Ribonuclease III;
p241
Peak binding time (min) 45.3
Cluster III
Cluster membership (corr) 0.994
Peak broadness (1 / std of log2 intensities) 1.16
Cluster expected from GO III
Subcellular localization (Human Protein Atlas)
Subcellular localization (Human Cell Map) NMF result: nuclear body, SAFE result: chromatin, nucleoplasm
RMSE (expected - observed) 0.15
Link to current annotations (QuickGO) QuickGO 🔗

mRNA binding dynamics


Gene Ontology based expectation (GO 2021-09-01)


Protein interactors of DROSHA in mRNP (BioGRID)


Master Protein UniProt Gene Symbol Peak binding time (min) Cluster Subcellular localization (Human Protein Atlas) Subcellular localization (Human Cell Map) Number of evidences (experiment types) Number of evidences (publications)
Q96SB4 SRPK1 52.0 IV Cytosol;Nucleus;Plasma membrane NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction 2 3
P27695 APEX1 53.4 III Nucleus NMF result: no prediction, SAFE result: no prediction 2 1
Q6NZY4 ZCCHC8 40.2 II Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: - 1 1
P17844 DDX5 40.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q69YN4 VIRMA 0.0 I Nuclear bodies;Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9Y2W1 THRAP3 37.2 II Nuclear speckles NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q9P2E3 ZNFX1 233.0 VII Mitochondria NMF result: no prediction, SAFE result: no prediction 1 1
Q9UBU9 NXF1 50.3 III Nucleoplasm NMF result: miscellaneous, SAFE result: nuclear pore 1 1
Q07666 KHDRBS1 43.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
O75340 PDCD6 37.8 II Cytosol NMF result: no prediction, SAFE result: no prediction 1 1
Q96PK6 RBM14 42.9 II Nuclear speckles NMF result: nuclear body, SAFE result: paraspeckles 1 1
P42285 MTREX 73.4 V Nucleus NMF result: chromatin, SAFE result: - 1 1
P27694 RPA1 45.5 III Nucleoplasm NMF result: chromatin, SAFE result: chromatin, nucleoplasm 1 1
Q99729 HNRNPAB 42.8 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
Q1KMD3 HNRNPUL2 42.7 II Nucleoplasm NMF result: no prediction, SAFE result: no prediction 1 1
O15042 U2SURP 33.1 II Nucleoplasm NMF result: nuclear body, SAFE result: splicing speckles, nucleolus 1 1
Q92945 KHSRP 37.0 II Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1
P49750 YLPM1 44.9 III Nuclear speckles;Nucleoplasm NMF result: nuclear body, SAFE result: paraspeckles 1 1