FMR1
| UniProt Accession | Q06787 UniProt 🔗 |
|---|---|
| Synonyms | |
| UniProt protein names | Fragile X messenger ribonucleoprotein 1;Fragile X messenger ribonucleoprotein;Protein FMR-1 |
| Peak binding time (min) | 176.8 |
| Cluster | VII |
| Cluster membership (corr) | 0.991 |
| Peak broadness (1 / std of log2 intensities) | 1.06 |
| Cluster expected from GO | VII |
| Subcellular localization (Human Protein Atlas) | Cytosol |
| Subcellular localization (Human Cell Map) | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule |
| RMSE (expected - observed) | 0.12 |
| Link to current annotations (QuickGO) | QuickGO 🔗 |
mRNA binding dynamics
Gene Ontology based expectation (GO 2021-09-01)
Protein interactors of FMR1 in mRNP (BioGRID)
| Master Protein UniProt | Gene Symbol | Peak binding time (min) | Cluster | Subcellular localization (Human Protein Atlas) | Subcellular localization (Human Cell Map) | Number of evidences (experiment types) | Number of evidences (publications) |
|---|---|---|---|---|---|---|---|
| P51116 | FXR2 | 171.1 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 6 | 10 |
| P51114 | FXR1 | 172.6 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 5 | 6 |
| Q9H7E2 | TDRD3 | 89.3 | VI | Cytosol;Golgi apparatus;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 5 | 4 |
| Q7Z417 | NUFIP2 | 124.8 | VI | Cytosol;Nuclear bodies;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 4 | 2 |
| Q13283 | G3BP1 | 220.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 2 | 2 |
| O95793 | STAU1 | 111.0 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 2 | 2 |
| Q9NYF8 | BCLAF1 | 37.5 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 2 | 2 |
| P19338 | NCL | 27.1 | II | Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q13435 | SF3B2 | 37.6 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: splicing speckles, nucleolus | 1 | 1 |
| Q9NZB2 | FAM120A | 158.5 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q14157 | UBAP2L | 212.4 | VII | Cytosol;Nuclear speckles | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9H000 | MKRN2 | 65.9 | V | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9Y5A9 | YTHDF2 | 111.0 | VI | Cytoplasmic bodies;Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q5TC82 | RC3H1 | 62.0 | IV | Cytosol;Plasma membrane | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q92615 | LARP4B | 233.7 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9UKV8 | AGO2 | 103.6 | VI | Cell Junctions;Nucleoplasm | NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched | 1 | 1 |
| Q9Y6M1 | IGF2BP2 | 159.3 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q99700 | ATXN2 | 116.5 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q8ND56 | LSM14A | 138.4 | VII | Cytoplasmic bodies;Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P46013 | MKI67 | 62.1 | V | Nuclear bodies;Nucleoli;Nucleus | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| O95985 | TOP3B | 72.2 | V | Vesicles | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9BYJ9 | YTHDF1 | 222.1 | VII | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 | |
| Q96PK6 | RBM14 | 42.9 | II | Nuclear speckles | NMF result: nuclear body, SAFE result: paraspeckles | 1 | 1 |
| Q9Y520 | PRRC2C | 147.3 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q8TB72 | PUM2 | 91.4 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9UGR2 | ZC3H7B | 80.7 | VI | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 | |
| P38919 | EIF4A3 | 67.1 | V | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q5JSZ5 | PRRC2B | 80.3 | V | Cytosol;Nuclear bodies | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P61326 | MAGOH | 70.2 | V | Nucleus | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| O15234 | CASC3 | 88.1 | VI | Nuclear membrane | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q5T6F2 | UBAP2 | 209.7 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9BRZ2 | TRIM56 | 74.3 | V | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: - | 1 | 1 |
| Q14444 | CAPRIN1 | 229.7 | VII | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 | |
| Q7Z739 | YTHDF3 | 111.3 | VI | Cytosol;Nuclear membrane;Nuclear speckles | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q17RY0 | CPEB4 | 87.8 | VI | Golgi apparatus;Nucleoplasm;Vesicles | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| O75534 | CSDE1 | 122.4 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q96I24 | FUBP3 | 51.8 | III | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles | 1 | 1 |
| Q92900 | UPF1 | 158.9 | VII | Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| O00571 | DDX3X | 146.2 | VII | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: no prediction | 1 | 1 |
| Q9UN86 | G3BP2 | 148.8 | VII | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P29558 | RBMS1 | 107.1 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q14671 | PUM1 | 104.1 | VI | Cytosol;Nucleus | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q13428 | TCOF1 | 0.0 | I | Nucleoli fibrillar center | NMF result: nucleolus, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q14694 | USP10 | 192.3 | VII | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q7Z2W4 | ZC3HAV1 | 211.8 | VII | Cytosol;Golgi apparatus | NMF result: nuclear outer membrane-ER membrane network, SAFE result: nuclear outer membrane-ER membrane network | 1 | 1 |
| Q71RC2 | LARP4 | 130.6 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q8WWM7 | ATXN2L | 117.4 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9HCE1 | MOV10 | 221.0 | VII | Cytosol | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| O60506 | SYNCRIP | 71.4 | V | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: paraspeckles | 1 | 1 |
| P08621 | SNRNP70 | 32.2 | II | Nucleoplasm | NMF result: no prediction, SAFE result: no prediction | 1 | 1 |
| Q01804 | OTUD4 | 99.3 | VI | Cytosol | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| P48634 | PRRC2A | 106.7 | VI | Cytosol;Nucleoplasm | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9C0B0 | UNK | 88.4 | VI | Cytoplasmic bodies;Cytosol | NMF result: centrosome, SAFE result: centrosome enriched, P-body enriched | 1 | 1 |
| Q14839 | CHD4 | 61.8 | III | Nucleus | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q6P158 | DHX57 | 78.3 | VI | Cytosol;Intermediate filaments;Microtubules;Nucleoli | NMF result: cytoplasmic ribonucleoprotein granule, SAFE result: cytoplasmic ribonucleoprotein granule | 1 | 1 |
| Q9Y3Y2 | CHTOP | 75.6 | V | Nuclear speckles | NMF result: chromatin, SAFE result: chromatin, nucleoplasm | 1 | 1 |
| Q12873 | CHD3 | 52.4 | IV | Microtubule organizing center;Nucleoli;Nucleus | NMF result: nucleoplasm, SAFE result: chromatin, nucleoplasm | 1 | 1 |